低氧對第二型糖尿病之影響

10.6162/SRR.2009.104.21

吳茂盛；王秉泰；方同賢；侯建文

第四型葡萄糖轉運體 ； 低氧誘發因子1α ； 內皮生長因子

大專體育

104期（2009 / 10 / 01）

152 - 158

繁體中文

第二型糖尿病是現今社會一個嚴重、昂貴及快速增加的疾病。肥胖會使身體產生抗胰島素現象進而影響全身血糖吸收能力。肌肉細胞膜上第四型葡萄糖轉運體(GLUT4)的數目為肌肉吸收血糖的關鍵因子。胰島素和單磷酸活化蛋白質激酶(AMPK)為影響第四型葡萄糖轉運體移位至細胞膜表面的主要因素。先前研究發現低氧可以增加AMPK活性與PGC-1α的表現量來改善血糖吸收能力，也可以經由Akt 提高低氧誘發因子1α (HIF-1α)蛋白量來增加第一型葡萄糖轉運體(GLUT1)和內皮生長因子(VEGF)的表現量。現今大部分的低氧研究都是使用極低的氧氣濃度來增加醣類吸收相關蛋白的表現量，所以未來可以探討比較適合人體應用的氧氣濃度來觀察醣類吸收相關蛋白的反應，以利於將來使用低氧預防及治療第二型糖尿病。

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