鋅在運動促進心肌保護功能降低缺血再灌流傷害的重要性

Importance of Zinc as Myocardial Protection to Reduce Ischemia-Induced Reperfusion Injury in Exercise

10.6162/SRR.2015.133.08

蔡佈曦(Pu-Hsi Tsai)；陳聰毅(Tsung-I Chen)

抗氧化 ； 氧化傷害 ； 活性氧物種 ； 活性氮物種 ； antioxidant ； oxidative stress ； reactive oxygen species ； reactive nitrogen species

大專體育

133期（2015 / 06 / 30）

54 - 61

繁體中文

近年來，鋅在人體內被認為是一種非常重要的礦物質，因為它具有抗氧化和抗發炎的雙重作用。本文以文獻回顧的方式，目的是探討鋅在運動提升心臟保護機制的重要性。研究結果發現心肌梗塞及鬱血性心臟衰竭患者有嚴重低血鋅及鋅／銅比值下降的現象。從糖尿病大鼠的研究中發現，補充鋅劑之糖尿病運動鼠，具有較高的超氧化物歧化酵素與穀胱甘肽過氧化酶等抗氧化酵素活性，進而降低心肌脂質過氧化程度。另外，臨床上治療急性心肌梗塞時，給予適量的鋅可能是避免缺血再灌流傷害的一個可行的策略，因此平時除了維持規律運動習慣之外，適時注意攝取適量鋅，對促進心臟保護功能將有更佳的效果。故建議未來研究方向可探討運動如何避免心臟鋅離子流失，以及提升心臟細胞鋅離子濃度，以增進心臟抵抗缺血再灌流之保護效果。

It has been suggested that severe hypozincemia and a decrease in copper/zinc ratio were found in the myocardium of patients with acute myocardial infarction and congestive heart failure. Recently, zinc has been considered one of the most important trace elements in the body because it has a dual effect of anti-inflammatory and antioxidant activities. A previous study reported that higher myocardial levels of superoxide dismutase and glutathione peroxidase activities were found in zinc-supplemented diabetic swimming rats, resulting in a decreased level in myocardial lipid peroxidation. In addition, pre-treatment with zinc before reperfusion may be a potential clinical strategy to provide the cardioprotective effects against ischemia-reperfusion injury. Thus, regular exercise, combined with adequate amounts of zinc supplementation, may be the most efficient way to enhance cardioprotective effects. It is suggested that future sports medicine research could explore how to avoid loss of zinc ion and zinc ion concentrations in the heart and improve heart cells, to enhance the effect myocardial protection against ischemia-reperfusion.

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