靜態行為造成肥胖與心血管疾病之生理機轉

Physiological Mechanisms Between Sedentary Behavior and Obesity/Cardiovascular Diseases

10.6162/SRR.202003_(152).0003

張家慧(Chia-Hui Chang)；范育瑄(Yu-Hsuan Fan)；薛名淳(Ming-Chun Hsueh)；黃翊軒(Yi-Hsuan Huang)

血糖 ； 胰島素 ； 三酸甘油酯 ； 血液流速 ； 賀爾蒙 ； blood sugar ； insulin ； triglyceride ； blood velocity ； hormone

大專體育

152期（2020 / 03 / 31）

32 - 39

繁體中文

「靜態行為」（亦稱為坐式生活）為21世紀新興的健康行為危險因子，研究證實以「靜態行為」為主的生活型態會增加死亡、罹患心血管疾病及與肥胖相關慢性疾病的風險。因此本文目的是以文獻回顧法介紹及彙整「靜態行為」與肥胖、心血管疾病之生理機轉。經過實驗室研究結果證實「靜態行為」對於人體產生的生理反應，主要包括血糖、胰島素、三酸甘油酯、血液流速的改變。靜態行為和肥胖之間存在正向關聯性的主因包括，長時間的坐式行為會使促進食慾的賀爾蒙量上升而攝取較多的熱量，此外靜態行為是低能量消耗行為，較少的熱量消耗與持續的熱量攝入將導致肥胖的產生。長時間的靜態行為會導致血液鬱積、血液容積下降、發炎、血管內皮受損，而提高罹患心血管疾病的風險。有鑑於慢性疾病已成為國人的主要死因之一，且大多和肥胖及其所引發危險因子有關，因此發展有效的策略以減少靜態行為的危害，為國家公共衛生的重要目標。

Sedentary behavior is an emerging behavioral risk factor for health in the 21st century. Although research has shown that a sedentary lifestyle is related to an increased risk of mortality and non-communicable diseases, only a limited number of studies have introduced the possible underlying causal mechanisms through which sedentary behavior contributes to cardiovascular diseases (CVD) or obesity. Thus, the purpose of this paper is to conduct a literature review examining the physiological mechanisms between sedentary behavior and obesity or CVD. The results of laboratory studies indicate that the physiological responses of sedentary behavior include changes in blood sugar, insulin, triglyceride, and blood velocity. One possible explanation for the positive association between prolonged sedentary behavior and obesity is that it contributes to the increase in levels of the hormone which can stimulate appetite and thus increase caloric intake. Sedentary behavior is also characterized as a low energy expenditure behavior; therefore, it is possible that decreased energy expenditure and increased energy intake may increase the incidence of obesity. Moreover, prolonged sedentary behavior causes blood stasis, low blood volume, inflammation, endothelial dysfunction, and increased cardiovascular disease risk. Given that the major causes of mortality in Taiwan are related to obesity and chronic diseases, it is important to develop effective strategies for reducing the negative impacts of sedentary behavior. These could also inform public health initiatives.

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