在葡萄糖攝取與運動壓力下頂尖跆拳道選手血糖恆定變化之研究

Glucose Homeostasis in Elite Taekwando Athletes under Glucose Feeding and Exercise Condition

10.5297/ser.200207_4(1).0014

秦玉芳(Yu-Fong Chin)；王秉泰(Ping-Tai Wang)；許東雄(Tung-Hsun Hsu)；陳美枝(Mei-Chi Chen)；卓玉敏(Yu-Min Cho)；邱麗玲(Li-Ling Chiu)；沈子斐(Chih-Wen Sen)；郭家驊(Chia-Hua Kuo)

胰島素敏感度 ； 葡萄糖吸收能力 耐受度 ； 跆拳道 ； 壓力 ； 血糖恆定 ； in vivo insulin sensitivity ； glucose tolerance ； Taekwando athletes ； stress ； glucose homeostasis

大專體育學刊

4卷1期（2002 / 07 / 31）

157 - 168

繁體中文;英文

本研究的主要目的，在於觀察頂尖跆拳道選手處於葡萄糖攝食與運動等兩種狀態下，血糖恆常濃度的控制能力。頂尖跆拳道選手與對照組（一般體育學院學生）共十二位女性受試者共同參與本研究，這兩組受試者於隔夜禁食後，進行葡萄糖耐受度測試與血液樣本之收集。在75公克葡萄糖攝取後，兩組受試者血液葡萄糖濃度均明顯提升，其中跆拳道選手在葡萄糖攝食後30與60分鐘的血糖之上升與回降濃度，均明顯較對照組的受試者低。在相同的實驗時程上，兩組受試者血液胰島素的濃度起伏與葡萄糖濃度變化等差異也類似。因此本研究發現，頂尖跆拳道選手在碳水化合物補充狀態下，對血液葡萄糖吸收能力，比一般運動員較為卓越，而此差異部份與全身胰島素敏感度有關。在運動壓力測試狀態下，所有受試者在相同配速下，進行15分鐘反複式爬坡跑，在完成運動後立即測量生長激素與血糖濃度，並與運動前（空腹狀態）作比較，來觀察運動所造成的壓力水準。這個運動明顯造成所有受試者生長激素濃度顯著上升，然而在頂尖跆拳道選手生長激素濃度昇高的幅度較對照組為少，顯示頂尖跆拳道選手在相同量的運動刺激下，身體所感受的壓力反應較小。在血糖濃度變化方面，跆拳道選手在運動後平均血糖濃度顯著比對照組高，顯示頂尖跆拳道選手在運動壓力狀態下防止血糖濃度下降的能力較佳。這些特質也許對於每天須應付數場比賽，而能源儲存時間相對短暫、且比賽動作兼具重複性、持續性與強度之不可預測性的運動競技具有功能上的重要性。

The purpose of the present study was to examine the degree of blood glucose fluctuation under glucose feeding and exercise conditions in elite Taekwando athletes. A group of elite Taekwando athletes (female, N=6) and PE students (female, N=6) as a control group carried out OGTT after an overnight fast. Following a 75-gram of glucose challenge, the blood glucose concentration of these elite Taekwando athletes was smaller at 30 and 60 min post than the control group. Insulin concentration followed a similar trend as the glucose fluctuation under this condition. These results indicated the better glucose tolerance in these elite Taekwando athletes is partially due to higher in vivo insulin sensitivity. All three groups of the subjects also performed a 15-min repeated hill running with the same pace. Blood growth hormone and glucose concentrations were measured before and after the exercise in both groups. The growth hormone response to the exercise was significantly greater in control subjects than the Taekwando athletes. Accordingly, these Taekwando athletes had a significantly greater post exercise blood glucose concentration compared to control group. We conclude that the elite Taekwando athletes had a characteristic of better maintenance of glucose homeostasis under feeding and exercise stress, and that trait may be important for them to cope with the chronic and repeated types of sports competition.

1. Bloom, S.R.,Johnson, R.H.,Park, D.M.,Rennie, M.J.,Sulaiman, W.R.(1976).Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals.Journal of Physiology,258(1)
2. Coderre, L.,Kandror, K.V.,Vallega, G.,Pilch, P.F.(1995).Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle.Journal of Biological Chemistry,270(46)
3. Cox, D.J.,Gonder-Frederick, L.A.,Schroeder, D.B.,Cryer, RE.,Clarke, W.L.(1993).Disruptive effects of acute hypoglycemia on speed of cognitive and motor performance.Diabetes Care,16(10)
4. Etgen, G. J. Jr.,Wilson, C. M.,Jensen, J.,Cushman, S. W.,Ivy, J. L.(1996).Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat.American Journal of Physiology,271
5. Goodyear, L.J.,Hirshman, M.F.,Smith, R.J.,Horton, E.S.(1991).Glucose transporter number, activity, and isoform content in plasma membranes of red and white skeletal muscle.American Journal of Physiology,261
6. Hvidberg, A.,Fanelli, C.G.,Hershey, T.,Terkamp, C.,Craft, S.,Cryer, P.E.(1996).Impact of recent antecedent hypoglycemia on hypoglycemic cognitive dysfunction in nondiabetic humans.Diabetes,45(8)
7. Kahn, B.B.,Lilly Iecture(1996).Glucose transport: pivotal step in insulin action.Diabetes,45(11)
8. Kjasr, M.,Kiens, M.,Hargreaves, M.,Ritcher, E.A.(1991).Influence of active muscle and their metabolic regulation.Journal of Applied Physiology,71
9. Koranyj, L.I.,Boiirey, R.E.,Vuorinen-Markkola, H.,Koivisto, V.A.,Mueckler, M.,Permutt, M.A.,Yki-Jarvinen, H.(1991).Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man.Diabetologia,34(10)
10. Kraemer, W.J.,Aguilera, B.A.,Terada, M.,Newton, R.U.,Lynch, J.M.,Rosendaal, G.,McBride, J.M.,Gordon, S.E.,Hakkinen, K.(1995).Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise.Journal of Applied Physiology,79(4)
11. Kuo, C.H.,Ding, Z.,lvy, J.L.(1996).Interaction of exercise training and clenbuterol on GLUT-4 protein in muscle of obese Zucker rats.American Journal of Physiology,271
12. Kuo, C.H.,Ivy, J.L.(1998).Regulation of GLUT4 protein expression and glycogen storage after prolonged exercise.Acta Physiologica. Scandinavica,165
13. Lavoie, C.,Ducros, F.,Bourque, J.,Langelier, H.,Chiasson, J.L.(1997).Glucose metabolism during exercise in man: the role of insulin and glucagon in the regulation of hepatic glucose production and gluconeogenesis.Canadian Journal of Physiology & Pharmacology,75(1)
14. Moller, N.,Jorgensen, J.O.,Moller, J.,Orskov, L.,Ovesen, P.,Schmitz, O.,Christiansen, J.S.,Orskov, H.(1995).Metabolic effects of growth hormone in humans.Metabolism: Clinical & Experimental,44
15. Muller, E.E.,Saito, T.,Arimura, A.,Schally, A.V.(1967).Hypoglycemia, stress and growth hormone release: blockade of growth hormone release by drugs acting on the central nervous system.Endocrinology,80(1)
16. Nevill, M.E.,Holmyard, D.J.,Hall, G.M.,Allsop, P.,van Oosterhout, A.,Burrin, J.M.,Nevill, A.M.(1996).Growth hormone responses to treadmill sprinting in sprint- and endurancetrained athletes.European Journal of Applied Physiology & Occupational Physiology,72(5-6)
17. Newsholrne, E.A.,Blomstrand, E.,Ekblom, B.(1992).Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids.British Medical Bulletin,48(3)
18. Reaven, G.M.(1988).Banting lecture 1988. Role of insulin resistance in human disease.Diabetes,37(12)
19. Reichard, G.A.(1961).Blood glucose metabolism in man during muscular work.Journal of Applied Physiology,16
20. Ren, J.M.,Marshall, B.A.,Gulve, E.A.,Gao, J.,Johnson, D.W.,Holloszy, J.O.,Mueckler, M.(1993).Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle.Journal of Biological Chemistry,268(22)
21. Romijn, J. A.,Coyle, E. F.,Sidossis, L. S.,Gastaldelli, A.,Horowitz, J. F.,Endert, E.,Wolfe, R. R.(1993).Regulation of endogenous fat and carbohydrate metabolism in relation to exercise inrp.ndry and duration.American Journal of Physiology,265
22. Rowell, L.B.,Masoro, E.J.,Spencer, M.J.(1965).Splanchnic metabolism in exercising man.Journal of Applied Physiology,20(5)
23. Sahlin, K.(1990).Muscle glucose metabolism during exercise.Annals of Medicine,22(3)
24. Silverman, H.G.,Mazzeo, R.S.(1996).Hormonal responses to maximal and subinaximal exercise in trained and untrained men of various ages.Journals of Gerontology. Series A. Biological Sciences & Medical Sciences.,51(1)
25. Wasserman, D.H.,Geer, R.J.,Williams, P.E.,Becker, T.,Lacy, D.B.,Abumrad, N.N.(1991).Interaction of gut and liver nitrogen metabolism during exercise.Metabolism,40
26. Wasserman, D.H.,Williams, P.E.,Lacy, B.D.,Green, D.R.,Cherrington, A.D.(1988).Importance of interhepatic mechanisms to gluconeogenesis from alanine during exercise and recovery.American Journal of Physiolog,254
27. Weltman, A.,Weltman, J.Y.,Womack, C.J.,Davis, S.E.,Blumer, J.L.,Gaesser, G.A.,Hartman, M.L.(1997).Exercise training decreases the growth hormone (GH) response to acute constant- load exercise.Medicine & Science in Sports & Exercise,29(5)