题名

運動選手胰島素敏感度之特質

并列篇名

Characteristics of Insulin Sensitivity in Various Types of Athletes

DOI

10.5297/ser.200909_11(3).0007

作者

吳明杰(Ming-Chieh Wu);陳九州(Chiu-Chou Chen);方雩(Yu Fang);蔡櫻蘭(Ying-Lan Tsai);陳秀華(Hsiu-Hua Chen);羅仁駿(Jen-Chun Lo);黃文成(Wen-Chen Huang)

关键词

運動訓練 ; 身體質量指數 ; 胰島素濃度 ; exercise training ; BMI ; insulin level

期刊名称

大專體育學刊

卷期/出版年月

11卷3期(2009 / 09 / 30)

页次

95 - 103

内容语文

繁體中文;英文

中文摘要

醣類為運動比賽過程主要的能源,而胰島素敏感度與醣類的吸收與儲存成正比。在臨床醫學上,血糖值廣泛地被作為葡萄糖耐受度受損和第二型糖尿病的預測指標。而大部分男性運動選手皆具正常血糖濃度,其不同空腹胰島素濃度是否可作為評估胰島素敏感度的差異,目前仍未清楚。本研究目的為了解不同空腹胰島素濃度男性運動選手的胰島素阻抗性差異。空腹血糖濃度達正常值範圍內(<100 mg/dl),總計31項465名運動專長選手為研究對象。所有受試者再依空腹胰島素濃度分成三組:低胰島素組(<5 mU/dl, n=146)、中胰島素組(5-9.9 mU/dl, n=218)和高胰島素組(>10 mU/dl, n=101)。本研究結果顯示:一、高胰島素組身體質量指數和BIA體脂肪率屬於體重過重的範圍(BMI: 25.4±0.4; BIA: 22.5±0.7),且兩者具高度正相關(r=0.786, p<.001);二、高胰島素組的胰島素阻抗性(HOMA-IR)為3.95±0.21、中胰島素組為1.56±0.02及低胰島素組為0.77±0.02,各組均達顯著差異(p<.001);三、空腹胰島素和HOMA-IR兩者呈現顯著高度相關(r=0.994, p<.001)。本研究結論顯示身體的胰島素阻抗性隨著體脂肪增加而提高,針對運動選手的代謝適能檢測方面,採用空腹胰島素濃度為檢驗胰島素敏感度的有效的方法。

英文摘要

Fasting plasma glucose is widely used to predict the impaired glucose tolerance and type 2 diabetes in various populations. The difference in fasting insulin levels for evaluating metabolic status in male athletes with normal glucose have not been demonstrated completely. Therefore, we designed this study to evaluate the insulin sensitivity in various types of athletes. In this study total 465 subjects from 31-types of sport events were participated as effective samples. All the subjects with normal plasma glucose (<100mg/dl) were matched for fasting insulin level and assigned them into three groups including: Low fasting insulin level (FIL, <5mU/dl, n=146), Medium FIL (5-9.9mU/dl, n=218), and High FIL (>10mU/dl, n=101). The results of this study showed that both BMI and fat percentage in high FIL group reaches grade-1 overweight, and a significant correlation between two obesity measures (r=0.786, p<.001). A mean HOMA-IR in three groups was significantly different from each other that is 0.77, 1.56, and 3.95 respectively. This results indicates that fasting insulin level in all subjects were significantly associated with HOMA-IR (r=0.994, p<.001). From this data it was concluded that insulin resistance was directly associated with increased body fat. In addition, measurements of both fasting insulin level and obesity standard degree are useful to predict the insulin resistance in various types of male athletes.

主题分类 社會科學 > 體育學
参考文献
  1. Brancati, F. L.,Wang, N. Y.,Mead, L. A.,Liang, K. Y.,Klag, M. J.(1999).Body weight patterns from 20 to 49 years of age and subsequent risk for diabetes mellitus: The Johns Hopkins precursors study.Archives of Internal Medicine,159,957-963.
  2. Burke, J. P.,Williams, K.,Narayan, K. M. V.,Leibson, C.,Haffner, S. M.,Stern, M. P.(2003).A population perspective on diabetes prevention: Whom should we target for preventing weight gain?.Diabetes Care,26(7),1999-2004.
  3. Charles, M. A.,Fontbonne, A.,Thibult, N.,Warnet, J. M.,Rosselin, G. E.,Eschwege, E.(1991).Risk factors for NIDDM in white population. Paris prospective study.Diabetes,40(7),796-799.
  4. Del Prato, S.,Leonetti, E.,Simonson, D. C.,Sheehan, P.,Matsuda, M.,DeFronzo, R. A.(1994).Effect of sustained physiological hyperinsulinemia and hyperglycemia on insulin secretion and insulin sensitivity in men.Diabetologia,37,1025-1035.
  5. Ferrannini, E.(1998).Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects.Endocrine Revises,19(4),477-490.
  6. Ferrannini, E.,Nannipieri, M.,Williams, K.,Gonzales, C.,Haffner, S. M.,Stern, M. P.(2004).Mode of onset of type 2 diabetes from normal or impaired glucose tolerance.Diabetes,53(1),160-165.
  7. Ferrannini, E.,Natali, A.,Bell, P.,Cavallo-Perin, P.,Lalic, N.,Mingrone, G.(1997).Insulin resistance and hypersecretion in obesity.Journal of Clinical Investigation,100,1166-1173.
  8. Ghiringhello, M. T.,Vieira, J. G.,Tachibana, T. T.,Ferrer, C.,Maciel, R. M.,Amioka, P. H.,Hauache, O. M.,de Oliveira, C. H.,Khawali, C.,Reis, A. F.(2006).Distribution of HOMA-IR in Brazilian subjects with different body mass indexes.Arquivos Brasileiros De Endocrinologia E Metabologia,50(3),573-574.
  9. Haffner, S. M.,Miettinen, H.,Gaskill, S. P.,Stern, M. P.(1995).Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans.Diabetes,44(12),1386-1391.
  10. Jago, R.,Wedderkopp, N.,Kristensen, P. L.,Møller, N. C.,Andersen, L. B.,Cooper, A. R.,Froberg, K.(2008).Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR.American Journal of Preventive Medicine,35(6),554-560.
  11. Jebb, S. A.,Elia, M.(1993).Techniques for the measurement of body composition: A practical guide.International Journal of Obesity and Related Metabolic Disorders,17,611-621.
  12. Ko, G. T.,Chan, J. C.,Yeung, V. T.,Chow, C. C.,Tsang, L. W.,Li, J. K.,So, W. Y.,Wai, H. P.,Cockram, C. S.(1998).Combined use of a fasting plasma glucose concentration and HbA1c or fructosamine predicts the likelihood of having diabetes in high-risk subjects.Diabetes Care,21(8),1221-1225.
  13. Matthews, D. R.,Hosker, J. P.,Rudenski, A. S.,Naylor, B. A.,Treacher, D. F.,Turner, R. C.(1985).Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.Diabetologia,28(7),412-419.
  14. Meyer, R. A.,Gruber, H. E.,Howard, B. A.,Tabor, O. B.,Murakami, T.,Kwiatkowski, T. C.,Wozney, J. M.,Hanley, E. N.(1999).Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog.Spine,24(8),747.
  15. Rao, G.(2001).Insulin resistance syndrome.American Family Physician,63,1159-1163.
  16. Rizzo, N. S.,Ruiz, J. R.,Oja, L.,Veidebaum, T.,Sjöström, M.(2008).Associations between physical activity, body fat, and insulin resistance (homeostasis model assessment) in adolescents: The European youth heart study.American Journal of Clinical Nutrition,87(3),586-592.
  17. Sapin, R.,Le Galudec, V.,Gasser, F.,Pinget, M.,Grucker, D.(2001).Elecsys insulin assay: Free insulin determination and the absence of cross-reactivity with insulin lispro.Clinical Chemistry,47(3),602-506.
  18. Shaw, J. E.,Zimmet, P. Z.,Alberti, K. G.(2006).Point: Impaired fasting glucose: The case for the new American Diabetes Association criterion.Diabetes Care,29(5),1170-1172.
  19. Shaw, J. E.,Zimmet, P. Z.,Hodge, A. M.,de Courten, M.,Dowse, G. K.,Chitson, P.,Tuomilehto, J.,Alberti, K. G.(2000).Impaired fasting glucose: How low should it go?.Diabetes Care,23(1),34-39.
  20. Snijder, M. B.,van Dam, R. M.,Visser, M.,Seidell, J. C.(2005).What aspects of body fat are particularly hazardous and how do we measure them?.International Journal of Epidemiology,35(1),83-92.
  21. Steppan, C. M.,Bailey, S. T.,Bhat, S.,Brown, E. J.,Banerjee, R. R.,Wright, C. M.,Patel, H. R.,Ahima, R. S.,Lazar, M. A.(2001).The hormone resistin links obesity to diabetes.Nature,409,307-312.
  22. Weyer, C.,Hanson, R. L.,Tataranni, P. A.,Bogardus, C.,Pratley, R. E.(2000).A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: Evidence for a pathogenic role of relative hyperinsulinemia.Diabetes,49(12),2094-2101.
  23. 行政院衛生署(2006)。台灣地區十大死亡原因統計調查。台北市:行政院衛生署。
  24. 林正常(1996)。運動生理學實驗指引。台北市:師大書苑出版社。
被引用次数
  1. 謝錦城、廖威彰(2010)。運動介入對糖尿病前期狀態之改善。大專體育,111,97-103。