题名

Effects of Glutamine Peptide Supplementation on Lipolysis and Plasma IL-6 Concentration after Endurance Exercise

并列篇名

耐力運動後補充麩醯胺酸胜肽對脂肪分解及血漿IL-6濃度的影響

DOI

10.5297/ser.1802.005

作者

傅正思(Cheng-Sze Fu);蔡佈曦(Pu-Hsi Tsai);陳文詮(Wen-Chyuan Chen);李淑玲(Shu-Lin Lee);何應志(Ying-Chih Ho)

关键词

生醣性胺基酸 ; 甘油 ; 游離脂肪酸 ; glucogenic amino acids ; glycerol ; free fatty acid

期刊名称

大專體育學刊

卷期/出版年月

18卷2期(2016 / 06 / 30)

页次

126 - 135

内容语文

英文

中文摘要

本研究目的在探討耐力運動後補充麩醯胺酸胜肽對恢復期血漿IL-6、生醣性胺基酸及脂肪分解的影響。實驗採用隨機雙盲交叉設計,研究對象為7名健康之大學男性學生,以強度75%V_4 O_2max之跑步機耐力運動60分鐘後補充麩醯胺酸胜肽或安慰劑 (0.1 g/kg.bw),於運動前、運動後第0、15、30、45、60、90及120分鐘時採集血液進行生化值之分析,檢定麩醯胺酸胜肽組(GP)及安慰劑組(PL)補充在運動前後各血點與兩組間各血點之差異。研究結果顯示:IL-6濃度在運動恢復期45及60分鐘時,GP組顯著高於PL組;甘油濃度在運動恢復期60及90分鐘時,GP組顯著低於PL組;生醣性胺基酸濃度在運動恢復期30分鐘時,GP組顯著高於PL組;血糖、胰島素及游離脂肪酸濃度在運動恢復期時,兩組之間並無顯著差異。本研究結論:運動恢復期補充麩醯胺酸胜肽,可增加升醣性胺基酸濃度、抑制脂肪分解作用並且增加血漿中IL-6的濃度。

英文摘要

The purpose of this study was to investigate the effects of glutamine peptide supplementation on plasma interleukin-6 (IL-6), glucogenic amino acids and lipolytic metabolite during recovery after endurance exercise. In this crossover designed study, seven healthy male college students completed either placebo (PL) supplementation or glutamine peptide (GP) supplementation trial in a randomized order. The subjects were assigned to run on a treadmill at an estimated speed corresponding to their 75% V_4 O_2max values for 60 min, where after the GP trial received 0.1 g/kg . bw glutamine-peptide solution and the PL trial received hydroxypropyl methylcellulose solution. The biochemical parameters in the blood sample were measured pre-exercise, and after exercise at 0, 15, 30, 45, 60, 90 and 120-min. Plasma IL-6 concentration was significantly greater in GP trial at 45 and 60 min during recovery periods. Furthermore, plasma glycerol was also significantly greater in GP trial during recovery at 60 and 90 min following exercise. Glucogenic amino acids in the GP trial were significantly increased at 30 min during recovery. Nevertheless, we found no significant differences in glucose, insulin and free fatty acid concentrations for both trials during recovery periods. In conclusion, the present study demonstrated that the GP supplementation can increase glucogenic amino acids, inhibit lipolysis and enhance plasma IL-6 concentrations in young adults during recovery following exercise.

主题分类 社會科學 > 體育學
参考文献
  1. Akira, S.,Taga, T.,Kishimoto, T.(1993).Interleukin-6 in biology and medicine.Advances in Immunology,54,1-78.
  2. Boschmann, M.,Rosenbaum, M.,Leibel, R. L.,Segal, K. R.(2002).Metabolic and hemodynamic responses to exercise in subcutaneous adipose tissue and skeletal muscle.International Journal of Sports Medicine,23(8),537-543.
  3. Cersosimo, E.,Williams, P.,Hoxworth, B.,Lacy, W.,Abumrad, N.(1986).Glutamine blocks lipolysis and ketogenesis of fasting.American Journal of Physiology,250(3),E248-E252.
  4. Christophe, J.,Winand, J.,Kutzner, R.,Hebbelinck, M.(1971).Amino acid levels in plasma, liver, muscle, and kidney during and after exercise in fasted and fed rats.American Journal of Physiology,221,453-457.
  5. Eriksson, L. S.,Broberg, S.,Björkman, O.,Wahren, J.(1985).Ammonia metabolism during exercise in man.Clinical Physiology,5(4),325-336.
  6. Fischer, C. P.,Bode, B. P.,Takahashi, K.,Tanabe, K. K.,Souba, W. W.(1996).Glucocorticoiddependent induction of interleukin-6 receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino acid transport.Annals of Surgery,223(5),610-619.
  7. Halseth, A. E.,Rhéaume, N.,Messina, A. B.,Reed, E. K.,Krishna, M. G.,Flakoll, P. J.,Wasserman, D. H.(1998).Regulation of hepatic glutamine metabolism during exercise in the dog.American Journal of Physiology - Endocrinology and Metabolism,275(4),E655-E664.
  8. Hiscock, N.,Mackinnon, L. T.(1998).A comparison of plasma glutamine concentration in athletes from different sports.Medicine & Science in Sports & Exercise,30(12),1693-1696.
  9. Hiscock, N.,Petersen, E. W.,Krzywkowski, K.,Boza, J.,Halkjaer-Kristensen, J.,Pedersen, B. K.(2003).Glutamine supplementation further enhances exercise-induced plasma IL-6.Journal of Applied Physiology,95(1),145-148.
  10. Iwashita, S.,Williams, P.,Jabbour, K.,Ueda, T.,Kobayashi, H.,Baier, S.,Flakoll, P. J.(2005).Impact of glutamine supplementation on glucose homeostasis during and after exercise.Journal of Applied Physiology,99(5),1858-1865.
  11. Jeukendrup, A. E.,Saris, W. H. M.,Wagenmakers, A. J. M.(1998).Fat metabolism during exercise: A review. Part I: Fatty acid mobilization and muscle metabolism.International Journal of Sports Medicine,19(4),231-244.
  12. Marion-Latard, F.,Crampes, F.,Zakaroff-Girard, A.,De Glisezinski, I.,Harant, I.,Stich, V.,Berlan, M.(2003).Post-exercise increase of lipid oxidation after a moderate exercise bout in untrained healthy obese men.Hormone and Metabolic Research,35(2),97-103.
  13. Nonogaki, K.,Fuller, G. M.,Fuentes, N. L.,Moser, A. H.,Staprans, I.,Grunfeld, C.,Feingold, K. R.(1995).Interleukin-6 stimulates hepatic triglyceride secretion in rats.Endocrinology,136(5),2143-2149.
  14. Ostrowski, K.,Hermann, C.,Bangash, A.,Schjerling, P.,Nielsen, J. N.,Pedersen, B. K.(1998).A trauma-like elevation in plasma cytokines in humans in response to treadmill running.The Journal of Physiology,513(3),889-894.
  15. Ostrowski, K.,Rohde, T.,Asp, S.,Schjerling, P.,Pedersen, B. K.(1999).Pro- and antiinflammatory cytokine balance in strenuous exercise in humans.The Journal of Physiology,515(1),287-291.
  16. Pedersen, B. K.,Steensberg, A.,Schjerling, P.(2001).Muscle-derived interleukin-6: Possible biological effects.The Journal of Physiology,536(2),329-337.
  17. Roef, M. J.,de Meer, K.,Kalhan, S. C.,Straver, H.,Berger, R.,Reijngoud, D. J.(2003).Gluconeogenesis in humans with induced hyperlactatemia during low-intensity exercise.American Journal of Physiology - Endocrinology and Metabolism,284(6),E1162-E1171.
  18. Rohde, T.,Asp, S.,McLean, D. A.,Pedersen, B. K.(1998).Competitive sustained exercise in humans, lymphokine-activated killer cell activity, and glutamine - An intervention study.European Journal of Applied Physiology and Occupational Physiology,78(5),448-453.
  19. Schoemaker, R. C.,Buijs, M. M.,Pijl, H.,Burggraaf, J.,Cohen, A. F.(2002).Modeling the influence of growth hormone on lipolysis.Journal of Pharmacokinetics and Pharmacodynamics,29(2),157-170.
  20. Steensberg, A.,van Hall, G.,Osada, T.,Sacchetti, M.,Saltin, B.,Pedersen, B. K.(2000).Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.The Journal of Physiology,529(1),237-242.
  21. Stouthard, J. M. L.,Oude Elferink, R. P. J.,Sauerwein, H. P.(1996).Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes.Biochemical and Biophysical Research Communications,220(2),241-245.
  22. Watkins, K. T.,Dudrick, P. S.,Copeland, E. M.,Souba, W. W.(1994).Interleukin-6 and dexamethasone work coordinately to augment hepatic amino acid transport.Journal of Trauma - Injury Infection & Critical Care,36(4),523-528.