單次口服肉鹼補充促進人體運動後骨骼肌肉肝醣再合成

Enhancing Glycogen Resynthesis after Acute Oral Carnitine Supplementation in Human Exercised Skeletal Muscle

10.5297/ser.1804.007

林峰樟(Fong-Chang Lin)；廖淑芬(Su-Fen Liao)；曹榮鑣(Jung-Piao Tsao)；蔡岑瑋(Tsen-Wei Tsai)；程一雄(I-Shiung Cheng)

運動恢復期 ； 增能劑 ； 胰島素敏感性 ； 肌肉樣本 ； exercise recovery ； ergogenic aids ； insulin sensitivity ； muscle sample

大專體育學刊

18卷4期（2016 / 12 / 31）

323 - 332

繁體中文;英文

本研究目的在探討單次口服肉鹼是否有利於促進人體運動後骨骼肌肉肝醣恢復。本次為交叉實驗設計，7名受試者（年齡：20.1 ± 0.3歲）隨機分派至肉鹼試驗（實驗組）或安慰劑試驗（安慰劑組），兩次實驗間隔至少7天。所有受試者接受單次60分鐘70%VO_(2max)腳踏車運動挑戰，運動立即後給予高碳水化合物飲食補充（每公斤體重2克碳水化合物，80%碳水化合物、8%脂肪、12%蛋白質）及口服補充肉鹼膠囊（2,000毫克）或安慰劑澱粉膠囊，同時觀察運動後恢復期3小時內的生理反應。腳踏車運動後第0、3小時從股外側肌採集肌肉樣本，同期間每30分鐘收集血液樣本和每60分鐘收集10分鐘氣體樣本。研究結果顯示實驗組肌肉肝醣含量增加率顯著增加，在血液生化值方面，兩組的血糖濃度在各時間點均無顯著差異，然而實驗組的胰島素反應顯著低於安慰劑組。同時運動恢復期間，實驗組呼吸交換率明顯低於安慰劑組，這代表運動恢復期口服肉鹼後身體是偏向以脂肪為主要能量來源。因此，本研究結論證實運動後立即口服肉鹼補充能顯著地提升人體運動後肌肉肝醣恢復。

The purpose of this study was to investigate the effect of acute oral carnitine supplementation on post-meal glycogen synthesis in exercised human skeletal muscle. Seven healthy male subjects (aged 20.1 ± 0.3 years) completed a 60-min cycling exercise at 70% VO_(2max), and received carnitine or placebo capsules in a cross-over study design. The entire study protocol was repeated after a 7-d washout period. All subjects consumed 2,000 mg carnitine or placebo capsules immediately after exercise with a high carbohydrate meal (2 g carbohydrate/ kg body weight; 80% carbohydrate, 8% fat, 12% protein), and recovered for 3-h after exercise. Muscle biopsy samples were obtained from the vastus lateralis immediately and 3-h after exercise. Simultaneously, blood and gas samples were collected during 3-h recovery period. We found that carnitine supplementation significantly enhanced the muscle glycogen resynthesis rate compared to placebo supplementation. The estimated post-meal insulin response was found to be significantly lower in carnitine supplemented trial compared to placebo trial during recovery. However, no significant differences in blood glucose levels were noticed between the trials. The data from respiratory quotient analysis during recovery showed lower response in carnitine trial, which indicates energy resource in carnitine tails is reliance on fat oxidation. Therefore, this study concludes that acute oral supplementation of carnitine immediately after exercise can enhance the glycogen recovery in exercised human skeletal muscle.

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