增補雙蔘對男性下坡跑後血流動力學與脫氫異雄固酮－硫酸鹽之影響

Effects of Panax ginseng and Salvia miltiorrhiza Supplementation on Arterial Hemodynamics and Dehydroepiandrosterone Sulfate in Men After Downhill Running Exercise

10.5297/ser.201812_20(4).0006

童亢(Kang Tung)；廖翊宏(Yi-Hung Liao)；鄭浩民(Hao-Min Cheng)；林信甫(Hsin-Fu Lin)

主動脈阻抗 ； 肌肉痠痛指數 ； 血壓 ； aortic characteristic impedance ； visual analog scale ； blood pressure

大專體育學刊

20卷4期（2018 / 12 / 31）

358 - 372

繁體中文

本研究旨在探討短期增補人蔘和丹蔘（簡稱雙蔘）對下坡跑之動脈血流動力學之影響，同時探討保護作用是否與脫氫異雄固酮－硫酸鹽(dehydroepiandrosterone sulfate, DHEA-S)生成有關。招募20名健康且無規律運動習慣之男性受試者，依隨機分配與雙盲原則，連續增補7天雙蔘（人蔘和丹蔘萃取物各1,750 mg／天）或安慰劑，增補完後24小時內以個人75%最大攝氧峰值(75% VO_(2peak))的速度，進行30分鐘下坡跑（-10度）運動，並於控制實驗、下坡跑運動前30分鐘、後90分鐘、24、48與72小時檢測血流動力學指標，包括頸動脈血壓、反射波壓力(backward pressure, Pb)、主動脈阻抗(aortic characteristic impedance, Zc)、心內膜下心肌活力率(subendocardial viability ratio, SEVR)，以及血清睪固酮、DHEA-S、肌酸激酶(creatine kinase, CK)、皮質醇濃度及肌肉痠痛指數。研究結果發現兩組平均CK值於下坡跑運動後24及48小時皆顯著高於運動前，且肌肉痠痛指數於運動後各時間點皆顯著高於運動前。安慰劑組的Pb與Zc在運動後48小時顯著高於運動前；雙蔘組之頸動脈壓於運動後24與48小時顯著低於安慰劑組；SEVR於運動後48與72小時顯著高於安慰劑組。兩組平均DHEA-S、睪固酮、皮質醇與睪固酮／皮質醇比皆無差異。本研究結論單次下坡跑運動可能會增加主動脈阻力，而利用雙蔘增補能快速恢復冠狀動脈血流指標，但效果與DHEA-S 反應途徑無直接關係。

The purpose of this study was to investigate the pre-supplementation effects of Panax ginseng and Salvia miltiorrhiza herbs against acute bout of downhill running exercise-induced changes in arterial hemodynamics and dehydroepiandrosterone sulfate (DHEA-S) levels in men. Twenty apparent healthy men were recruited, and randomly assigned into experimental (Panax ginseng and Salvia miltiorrhiza supplementation) or placebo trials. Peak oxygen uptake (VO_(2peak)) of participants was determined prior to experiment followed by a 30 min downhill running at -10° of slope that could elicit 75% of individual VO_(2peak). Arterial hemodynamics, including carotid blood pressure (BP), backward pressure (Pb), aortic characteristic impedance (Zc), subendocardial viability ratio (SEVR), serum DHEA-S, cortisol, testosterone, creatine kinase (CK) and visual analog scale (VAS) were measured at rest, 30 min before exercise (pre-exercise), and 24, 48 and 72 hr after exercise (post-exercise). The results showed that CK activity was significantly elevated at 24 and 48 hr after exercise in both trials compared with baseline. The values of VAS at 90 min, 24 and 48 hr after exercise were significantly higher than the pre-exercise values in both trials. Furthermore, Pb and Zc values at 48 hr after exercise were significantly increased in placebo trial. However, post-exercise carotid systolic and mean BP in experimental trial was significantly lower at 24 and 48 hr compared to the placebo trial. SEVR of the experimental trial was significantly higher than that of placebo trial. Besides, DHEA-S, cortisol, testosterone and its ratio did not change throughout the study. Our study concludes that acute downhill running appears to increase the peripheral and aortic resistance. Panax ginseng and Salvia miltiorrhiza supplementation could attenuate the exercise-induced arterial stiffening effects and enhance coronary flow. However, the underlying mechanism may not be directly associated with DHEA-S response in healthy men.

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