H1N1 Vaccination may Transient Increased Seizure Frequency in Epileptic Children

正常兒童與癲癇病人流感（H1N1）疫苗注射後的未預期突發事件

李英齊(Inn-Chi Lee)

H1N1疫苗 ； 癲癇 ； 兒童 ； H1N1 vaccination ； epilepsy ； children

中山醫學雜誌

24卷1期（2013 / 06 / 01）

69 - 76

英文

大多數兒童對H1N1流感疫苗無特別反應，只有少數兒童接種疫苗後會出現未預期的神經反應（unexpected neurological events）。在此，對53個癲癇兒童調查，發現在施打疫苗的兒童，在接種疫苗後二個禮拜內抽搐有增加的情形（P = 0.008），之後所有的病人均完全復原。結論為臨床醫師應注意在一些癲癇兒童，在施打H1N1流感疫苗後，可能會增加抽搐頻率。

Most children tolerated well the H1N1 vaccine and adverse post-vaccination neurological effects are unusual. We report two case-series of transient unexpected neurological events (UNE) that occurred in two groups of children after they had been given an H1N1 vaccination. The second group consisted of 53 children with epilepsy, 28 of whom had been vaccinated, who were being regularly followed-up. Seizure frequencies were significantly higher in the vaccinated group (P = 0.008). All patients totally recovered without consequences. We concluded that some children manifest transient unexpected neurological events (UNE) after vaccination, particularly in epileptic children.