The efficacy of Single-Session Treatment of Recurrent Thyroid Cystic Nodules with Percutaneous Ethanol Injection

Kai-Lun Cheng；Shih-Chun Kuo；Yung-Yin Cheng；Hsiang-Lin Lee

Ultrasound ； Ethanol ； Thyroid cystic nodule ； Sclerotherapy

中山醫學雜誌

35卷1期（2024 / 06 / 01）

1 - 8

英文

Purpose: The aim of this study was to evaluate the efficacy of single-session treatment of recurrent thyroid cystic nodules with percutaneous ethanol injection (PEI).Method: Forty recurrent thyroid cystic nodules in 40 patients were treated with ultrasound-guided single-session PEI of 95% ethanol from January 2018 to June 2020. Follow-up ultrasound was performed 1, 3 and 6 months after PEI. At baseline and each follow-up examination, nodule volume, thyroid function, the symptom score (0-10), the cosmetic grade (1-4), volume reduction ratio (VRR) and complications were evaluated. Therapeutic success was defined as VRR > 50% at last follow up. Results: Mean volume of the index nodule was 22.7 ± 21.8 mL (range, 2.6-100 mL). After PEI, it decreased at 1 month (5.60 ± 5.99 mL, p<0.0001), 3 months (2.55 ± 3.57 mL, p<0.0001) and 6 months (1.24 ± 2.02 mL, p<0.0001). The therapeutic success rate was 100% and the mean VRR was 93.5% ± 7.81% for all treated nodules at last follow-up. The mean symptom score decreased from 6.18 ± 0.59 to 0.65 ± 0.58 and the mean cosmetic grade also decreased from 4.00 ± 0.00 to 1.10 ± 0.30 at last follow up. The thyroid function was normal at baseline and after PEI. No major complications were noted at the procedure or during follow up. Conclusion: Single-session PEI might be effective for the treatment of recurrent thyroid cystic nodules.