模組組裝與模型整合：以現代免疫學的發現為案例

Assembling Modules and Integrating Models:A Case of Discovery from Modern Immunology

10.6464/TJSSTM.202204_(34).0003

葉筱凡(Hsiao-Fan YEH)

模組 ； 組裝 ； 發現 ； 證成 ； 免疫學 ； module ； assembling ； discovery ； justification ； immunology

科技醫療與社會

34期（2022 / 04 / 01）

55 - 102

繁體中文

本文以模組組裝和模型整合觀點發展現代免疫學的發現模式。免疫學家為說明發炎反應現象，通常會從背景知識擷取可用的機制模組，將其與推測有因果關聯的機制成份拼裝出一個新的機制模型，然後用之設計干預實驗，產生多個資料模組進而組成資料模型，作為新發現的證據。過程中，免疫學家須在機制、實驗與資料三種模型內建立模組間的因果連續性，並且使三種模型的結果達成一致。本文爭論，免疫學家是透過建立模型內因果連續性與整合異質模型間的一致性來層層構成發現證成。由於此觀點是將先前哲學重視以機制假說或實驗現象為主的研究對象拆解為單位更小的模組，故打破傳統以假說或現象為主的二分。本文以一篇當代免疫學論文為分析案例，為新觀點提供證據。

This paper proposes a module-based analysis of the discovery process in the current practice of immunologists, focusing on their published results. In their explanations of inflammatory response phenomena, immunologists usually start by scouring the available background knowledge on mechanistic modules and reassembling a select module(s) and its causally relevant components to construct a new mechanistic model. Then they employ their model to design interventional experiments, and, lastly, articulate the data modules with data models to illustrate the putative evidence. In the process, scientists not only establish the causal continuity of modules within mechanistic, experimental, and data models but achieve consistency among them. In this paper, I argue that in their research articles immunologists' discovery pattern consists of forming layers of justification by assembling modules into modes and integrating heterogenous models. The module-based analysis of discovery patterns disrupts the traditional dichotomy between hypothesis-driven and phenomena-driven analyses. Compared to previous philosophical accounts, it better characterizes the generation of discoveries, as evidenced in a detailed analysis of the presentation of research results in an immunology article.

1. Ankeny, Rachel,Chang, Hasok,Boumans, Marcel,Boon, Mieke(2011).Introduction: Philosophy of Science in Practice.European Journal for Philosophy of Science,1,303-307.
2. Bechtel, William,Abrahamsen, Adele(2005).Explanation: A Mechanist Alternative.Studies in History and Philosophy of Biological and Biomedical Sciences,36,421-441.
3. Bechtel, William,Richardson, Robert C.(1993).Discovery Complexity: Decomposition and Localization as Strategies in Scientific Research.Princeton, N.J.:Princeton University Press.
4. Boumans, Marcel,Leonelli, Sabina(2013).Introduction: On the Philosophy of Science in Practice.Journal for General Philosophy of Science,44,259-261.
5. Burian, Richard M.(1997).Exploratory Experimentation and the Role of Histochemical Techniques in the Work of Jean Brachet, 1938-1952.History and Philosophy of the Life Science,19,27-45.
6. Burian, Richard M.(2007).On MicroRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology.History and Philosophy of the Life Sciences,29,285-311.
7. Chao, Hsiang-Ke,Chen, Szu-Ting,Millstein, Roberta L.(2013).Towards the Methodology Turn in the Philosophy of Science.Mechanism and Causality in Biology and Economics,New York:
8. Chen, Ruey-Lin(2013).Experimental Discovery, Data Models, and Mechanisms in Biology: An Example from Mendel’s Work.Mechanism and Causality in Biology and Economics,New York:
9. Craver, Carl F.,Darden, Lindley(2013).In Search of Mechanisms: Discoveries Across the Life Sciences.Chicago:University of Chicago Press.
10. Craver, Carl F.,Darden, Lindley(2001).Discovering Mechanisms in Neurobiology: The Case of Spatial Memory.Theory and Method in the Neurosciences,Pittsburgh, PA:
11. Darden, Lindely,Craver, Carl F.(2002).Strategies in the Interfiled Discovery of the Mechanism of Protein Synthesis.Studies in History and Philosophy of Biological and Biomedical Sciences,33,1-28.
12. Darden, Lindley(2002).Strategies for Discovering Mechanisms: Schema Instantiation, Modular Subassembly, Forward/Backward Chaining.Philosophy of Science (Supplement),69,S354-S365.
13. Darden, Lindley(2006).Reasoning in Biological Discoveries: Essays on Mechanisms, Interfield Relations, and Anomaly Resolution.New York:Cambridge University Press.
14. Darden, Lindley(1991).Theory Change in Science: Strategies from Mendelian Genetics.New York:Oxford University Press.
15. Elliott, Kevin C.(2007).Varieties of Exploratory Experimentation in Nanotoxicology.History and Philosophy of the Life Sciences,29(3),313-336.
16. Franklin, Laura R.(2005).Exploratory Experiments.Philosophy of Science,72,888-899.
17. Glennan, Stuart S.(2002).Rethinking Mechanistic Explanation.Philosophy of Science,69(S3),S342-S353.
18. Glennan, Stuart S.(1996).Mechanisms and the Nature of Causation.Erkenntnis,44,49-71.
19. Hacking, Ian(1983).Representing and Intervening.Cambridge:Cambridge University Press.
20. Hanson, Norwood R.(1958).Patterns of Discovery.Cambridge:Cambridge University Press.
21. Hempel, Carl G.(1965).Aspects of Scientific Explanation, and Other essays in the Philosophy of Science.New York:The Free Press.
22. Machamer, Peter,Darden, Lindley,Craver, Carl(2000).Thinking about Mechanisms.Philosophy of Science,67,1-25.
23. Masri, Mohamad F. B.,Mantri, Chinmay K.,Rathore, Abhay P. S.,John, Ashley L. St.(2019).Peripheral Serotonin Causes Dengue Virus-Induced Thrombocytopenia through 5HT2 Receptors.Blood,133(21),2325-2337.
24. O’Malley, Maureen A.(2007).Exploratory Experimentation and Scientific Practice: Metagenomics and the Proteorhodopsin Case.History and Philosophy of Life Science,29(3),335-360.
25. Pardee, Authur B.,Jacob, Francois,Monod, Jacques(1959).The Genetic Control and Cytoplasmic Expression of "Inducibility" in the Synthesis of β-galatosidase.Journal of Molecular Biology,1,165-178.
26. Popper, Karl(1959).The Logic of Scientific Discovery.New York:Harper & Row, Publishers.
27. Ruse, Michael(ed.)(2008).Handbook of Philosophy of Biology.Oxford:Oxford University Press.
28. Schaffner, Kenneth(1974).Logic of Discovery and Justification in Regulatory Genetics.Studies in History and Philosophy of Science,4(4),349-385.
29. Schaffner, Kenneth(1993).Discovery and Explanation in Biology and Medicine.Chicago:University of Chicago Press.
30. Waters, C. Kenneth(2007).The Nature and Context of Exploratory Experimentation: An Introduction to Three Case Studies of Exploratory Research.History and Philosophy of Life Science,29,275-284.
31. Waters, C. Kenneth(2004).What Was Classical Genetics?.Studies in History and Philosophy of Science,35(4),783-809.
32. Wimsatt, William(1972).Complexity and Organization.PSA 1972, Proceedings of the Philosophy of Science Association,Dordrecht:
33. Woodward, James(2003).Making Things Happen: A Theory of Causal Explanation.New York:Oxford University Press.
34. Yeh, Hsiao-Fan,Chen, Ruey-Lin(2017).An Experiment-Based Methodology for Classical Genetics and Molecular Biology.Annals of the Japan Association for Philosophy of Science,26,39-60.
35. 史書美（編）,梅家玲（編）,廖朝陽（編）,陳東升（編）(2019).台灣理論關鍵詞.臺北:聯經.
36. 林以行（編）(2016).登革熱的台灣經驗：從流行病學及臨床到基礎科學的新視野.臺北:科技部臺灣重要新興感染症研究計畫辦公室.
37. 陳瑞麟(2012).認知與評價：科學理論與實驗的動力學.臺北:臺大出版中心.
38. 葉筱凡（2020），〈生物學中的機制 〉。王一奇（編 ），《華文哲學百科》（ 2020 版本 ）。http://mephilosophy.ccu.edu.tw/entry.php?entry_name=生物學中的機制。

1. (2023)。探索生物學新模型：從睡衣實驗到乳糖操縱組。東吳哲學學報，47，147-184。