過重者代謝症候群與胰島素阻抗之相關性探討

The Association between Metabolic Syndrome and Insulin Resistance in Overweight Cases

10.7023/TJFM.200609.0181

詹欣隆(Hsin-Lung Chan)；黃麗卿(Lee-Ching Hwang)

metabolic syndrome ； insulin resistance ； HOMA-IR ； overweight

台灣家庭醫學雜誌

16卷3期（2006 / 09 / 01）

181 - 191

繁體中文

Three hundred and thirty-one volunteers, who were overweight and had high body mass index (BMI≧24 kg/m^2), participated in this study. They were required to fill up their medical history, life style, and family history. Their body weight, height, waist, hip circumference, and blood pressure (BP) were then measured. The blood was sampled to determine the fasting plasma glucose (FPG), insulin level, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). Quantification of insulin resistance (IR) was evaluated by the formula of Homeostatic Model Assessment Index-Insulin Resistance (HOMA-IR). The metabolic syndrome (MS) was defined by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and was modified by Asian-Pacific standard. The obtained results showed that the MS presented by the level of BP, total cholesterol, plasma insulin, TG, and HDL-C was higher in men than women. Average IR and log IR levels were significantly higher in men than women (p＜0.05). IR values obtained from both men and women were all correlated with the MS. However, this correlation displayed gender difference that all of these five items of the MS for women were correlated with the IR and only two items (TG and FPG) of the MS for men were associated with the IR. Data from regression analyses showed that women had four of these five MS items excluding high BP while men had only one item (high FPG) to be positively related to the IR. Based on these results observed, we conclude that there is a positive correlation and gender difference between the IR and MS.

Three hundred and thirty-one volunteers, who were overweight and had high body mass index (BMI≧24 kg/m^2), participated in this study. They were required to fill up their medical history, life style, and family history. Their body weight, height, waist, hip circumference, and blood pressure (BP) were then measured. The blood was sampled to determine the fasting plasma glucose (FPG), insulin level, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). Quantification of insulin resistance (IR) was evaluated by the formula of Homeostatic Model Assessment Index-Insulin Resistance (HOMA-IR). The metabolic syndrome (MS) was defined by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and was modified by Asian-Pacific standard. The obtained results showed that the MS presented by the level of BP, total cholesterol, plasma insulin, TG, and HDL-C was higher in men than women. Average IR and log IR levels were significantly higher in men than women (p＜0.05). IR values obtained from both men and women were all correlated with the MS. However, this correlation displayed gender difference that all of these five items of the MS for women were correlated with the IR and only two items (TG and FPG) of the MS for men were associated with the IR. Data from regression analyses showed that women had four of these five MS items excluding high BP while men had only one item (high FPG) to be positively related to the IR. Based on these results observed, we conclude that there is a positive correlation and gender difference between the IR and MS.

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