麻醉前鎮靜給藥對犬propofol全程靜脈麻醉之影響

Effects of Sedative Premedications on Propofol Total Intravenous Anesthesia in Dogs

10.7009/TVJ.200712.0186

蔣雨青(Yu-Ching Chiang)；葉力森(Lih-Seng Yeh)

犬 ； propofol ； 全靜脈麻醉 ； 麻醉前鎮靜給藥 ； 麻醉恢復 ； anesthesia recovery ； dog ； propofol ； sedative premedication ； total intravenous anesthesia

臺灣獸醫學雜誌

33卷3&4期（2007 / 12 / 01）

186 - 193

繁體中文

本報告為比較給予及不給予麻醉前鎮靜給藥的propofol全靜脈麻醉間差異之回溯性研究。研究對象為需要接受propofol全身麻醉且臨床上無重大健康問題的77隻犬隻。犬隻共分為三組，分別為未給予麻醉前鎮靜給藥(PT)，給予acepromazine 0.05 mg/kg IV做為麻醉前給藥(AT)，以及給予diazepam 0.3 mg/kg IV做為麻醉前給藥(DT)。本研究中比較了三組間所需propefol之劑量、麻醉中生命現象、麻醉後恢復時間及恢復狀況的差異。結果顯示雖然AT組犬隻誘導麻醉平均所需propofol劑量較PT組為低，但其麻醉中平均心跳數和平均動脈收縮壓亦較PT組為低，且犬隻自發站立所需時問也顯著較PT組延長。DT組之各項結果與PT組並無顯著差異。本研究顯示，在健康犬之propofol全靜脈麻醉中，麻醉前鎮靜給藥除了鎮靜效果外，並無法提供其他臨床上正面之效益。

The aim of this retrospective research is to study the influence of sedative premedication to propofol total intravenous anesthesia (TIVA). Seventy-seven clinically healthy, client-owned dogs were included in the study. Dogs were allotted to three groups: dogs without sedative premedication (PT), dogs with acepromazine 0.05 mg/kg IV (AT), and dogs with diazepam 0.3 mg/kg IV (DT). Dosage of propofol for anesthesia induction and maintenance, cardiovascular and ventilation condition during anesthesia, and recovery status were compared between groups. The results revealed that dogs in AT group, comparing to those in DT group, had lower mean heart rate and mean systolic arterial pressure during anesthesia, and took more time to be able to stand spontaneously, despite of less propofol dosage required for anesthesia induction. All measurement of DT group showed no significant differences to those of PT group. The study suggests that, unless chemical restraint is an issue, sedative premedications provide no clinical benefit to healthy dogs requiring propofol TIVA.