抗生素研發的再起－全新的標靶

Resurgence of Antibiotic Agents: Novel Targets

10.6526/ICJ.201104_21(2).0005

鍾欣怡(Hsing-Yi Chung)；彭銘業(Ming-Yieh Peng)

抗生素 ； 新興標靶 ； Antibiotic ； novel targets

感染控制雜誌

21卷2期（2011 / 04 / 01）

111 - 117

繁體中文

人類使用抗生素治療細菌性感染的歷史雖不到一百年，多重抗藥性菌株卻已悄然生成，如今這些抗藥細菌已成為人類健康所面對的重要問題。直至今日已有學者認為無藥可用的“後抗生素年代”已經來臨，因此全新抗生素的研發是刻不容緩的事情。學者們在細菌細胞壁合成步驟及細胞壁外尋找不同的作用標靶，期望能跳脫以往抗生素設計所使用的框架進而創造出新一代的抗生素。在本文中將介紹新興抗生素研發的標靶篩選方式，以及整理出目前進行的抗生素研究中的標靶，並提供一種抗生素的新治療思維。希望這些研究最終能開發出全新的抗生素，以延續人類使用抗生素的時代。

The use of antibiotics for treating bacterial infections had started recently-not more than 100 years ago. The evolution of several strains of antibiotic-resistant bacteria has become commonplace. Today, the increasing number of multidrug-resistant bacteria is a threat to human health. Some researchers even claim that we are approaching the post-antibiotic era. Therefore, there is an urgent need to develop new antibiotics. Many researchers are seeking different targets involved in bacterial cell wall synthesis, against which a new generation of antibiotics can be created using a novel scaffold. This article introduces novel phenotypic screens and antibiotic targets and also provides new strategies for treating bacterial infections. We hope that this work will aid the development of novel antibiotics and prolong the antibiotic era.