流行性感冒抗病毒藥劑的臨床使用

Clinical use of antiviral drugs in influenza

10.6526/ICJ.202012_30(6).0002

陳怡君(Yi-Chun Chen)；劉建衛(Jien-Wei Liu)

流行性感冒 ； 抗病毒藥 ； 組合治療 ； influenza ； antiviral agents ； combination therapies

感染控制雜誌

30卷6期（2020 / 12 / 01）

341 - 348

繁體中文

儘管流行性感冒已有疫苗能廣泛地獲得使用，它仍持續代表著嚴重的健康問題，我們需要有更好的抗病毒藥物用於治療重症患者並減緩大流行的影響。不同作用機轉藥物的開發為治療提供了新的選擇，而目前新的藥物與現有藥物相比亦展現出較顯著臨床改善的功效。另外，從動物實驗結果來看，結合兩種以上抗病毒藥物的組合有機會提高治療效果，臨床成效如何，尚待試驗證實。

Despite wide availability and use of vaccines against the disease, influenza remains a serious ongoing health issue. We need better Antiviral drugs to treat patients with clinically severe influenza and to mitigate the impacts of an influenza epidemic. A number of the new compounds were documented reported to be more clinically effective as compared with currently available drugs when treatment is initiated ＞ 48 hours after emergence of symptoms. In addition, in vitro and in vivo experiments have shown the demonstrated synergistic effects of many of the new compounds with conventional neuraminidase inhibitors. The clinical effectiveness of combined antiviral drugs in the treatment of influenza needs to be confirmed by clinical experiments.