化妝品用中藥材之安全性

Safety Testing of Chinese Herbs in Cosmetics

10.30001/JIES.200212.0003

官常慶；陳玉芬；方秀蓉；林獻財

中藥材 ； 皮膚刺激性 ； 眼睛刺激性 ； 單一劑量毒性

美容科技學刊

1卷1期（2002 / 12 / 01）

17 - 38

繁體中文

可供化妝品用之中藥材，首先要了解其安全性，因爲使用對象爲人的皮膚，依化妝品定義，皮膚作用溫和，不產生任何傷害，因此用在化妝品之中藥材，需先完成安全性試驗，充分了解中藥材對皮膚的影響。 此計畫先選擇十五種較常用於中藥化妝品的中藥材做試驗，其爲：白芷、茯苓、白芨、杏仁、當歸、天花粉、檀香、知母、何首烏、天門冬、麥門冬、紫草、黃苓和黃耆等。藥材經確認後，用水萃取和50%酒精萃取，過濾之，取其萃取液測試之。 依照常用的Draize氏法和Ames氏法以及其他的修改方法，用兔子、大白鼠、小白鼠和沙門氏菌，作爲測試對象，兔子皮膚刺激性試驗結果，上述十五種藥材，除了當歸、紫草表現輕微的刺激性，其他的中藥材萃取液，沒有刺激的現象。兔子眼睛刺激性採用低劑量眼睛刺激性試驗，十五種中藥材，均沒有明顯的眼睛刺激性。單一劑量毒性試驗，十五種中藥材之萃取液，一次口服劑量在10000mg/kg時，均沒有明顯毒性反應。Ames氏的基因突變試驗，由衛生署中醫藥委員會的研究計劃報告中，委託陽明醫學院廖志飛的計劃，整理出致突變性的結果顯示白芷有致突變性。

Cosmetics are applied to moisturize skin and hair, stimulate smell, deodorize, and enhance normal, appearance. Since cosmetics are applied on human skin, they should not contain any ingredients that may cause adverse health effects Chinese herbs are common ingredients in cosmetics. Thus, the evaluation of safety for the usage of Chinese herbs as the ingredients in the cosmetics formulation is necessary and plays an important role. Both the aqueous and the ethanol extracts of fifteen Chinese herbs will investigate for the evaluation of safety. These fifteen Chinese herbs are: Angelicae dahuricae, Poriacocos, Bletilla striata, Armeniaca mandshurica, Angelicae sinensis, Trichosanthes kirilowii, Panax ginseng, Santalum album, Anemarrhena asphodeloides, Polygonum multiflorum, Asparagus cochinchinensis, Ophiopogon japonicus, Lithospermum erythrorhizon, Scuteliaria baicalensis, and 1-ledysarum mongholicum. The Draize test and its modifications were used to identify irritants in this study. The test subjects were rabbits and white rats. The rabbit skin test results showed that only the 50% alcohol solutions containing Angeliea sinensis and Lithospermum erythrorhizon had mild irritation, while no reactions were found with other solutions. The eyes of the rabbits had no reaction to all fifteen herbs while performing the low- volume eye irritation test. The acute toxicity test showed that within dose of 10000 mg/kg, all fifteen herbs had no significant toxicity reaction.

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