聚麩胺酸／聚乙烯醇混摻薄膜接枝左旋維他命C之研究

Investigation of PGA/PVA Blend Membrane Grafted with L-vitamin C

10.30001/JIES.200903.0009

蘇德利(Te-Li Su)；楊銘乾(Ming-Chien Yang)；劉憓陵(Huey-Ling Liu)

聚麩胺酸 ； 聚胜肽 ； 聚乙烯醇 ； 戊二酫 ； 左旋維他命C ； 化妝品 ； PGA ； polypeptides ； PVA ； glutaraldehyde ； ascorbic ； cosmetic

美容科技學刊

6卷1期（2009 / 03 / 01）

77 - 94

繁體中文

Na+-γ-Poly (glutamic acid) (PGA)為一具有奇佳的高吸水性、生物可分解性、保濕性、無毒性等優良特性之高分子聚合物，因此用來與聚乙烯醇(PVA)泥摻製成薄膜。兩種高分子在室溫下且不需任何化學藥劑的條件下PGA和PVA即可混合形成水膠。依不同比例之PGA/PVA (0%、10%、11.1%、12.5%、20%、273%、30%、40%、50%)混摻薄膜測試在生理食鹽水中之膨潤度，證實其具有高吸濕性，之後以戊二酫與左旋維他命C共價結合，運用左旋維他命C之抗氧化能力，期能增加PGA/PVA混摻薄膜在生醫材料及化妝保養品產業上的應用。

Na+-γ-poly (glutamic acid) (PGA), a highly water-soluble, biodegradable, hygroscopic and non-cytotoxic polypeptides, was chosen to fabricate the PGA/polyvinyl alcohol (PVA) blending membranes. By mixing PGA and PVA together, a hydrogel would be formed at room temperature without any chemical treatment. It was proven to be a highly hygroscopic by mixing at different ratio of PGA/PVA (0~50%) blending membranes for testing its swelling ratio in normal saline. By glutaraldehyde to covalently bond L(+)-Ascorhic acid with PGA/PVA, the application of PGA PVA blending membranes can be broadened in medical devices and cosmetic indststries.

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