化妝（保養）品、環境荷爾蒙－乳癌之誘因

Cosmetics and Environmental Hormone Sensitive Breast Cancer

10.30001/JIES.201003.0009

邵東子(Dong-Zi Shao)

雌激素 ； 化妝 ； 保養品 ； 乳癌 ； 環境荷爾蒙

美容科技學刊

7卷1期（2010 / 03 / 01）

123 - 134

繁體中文

「環境荷爾蒙」是環境中外來的某種化學物質，原本在體內不存在，身體內分泌系統受到外來化學物質擾亂，產生基因突變及與生殖有關的種種異常反應，許多關於環境中具雌激素活性的化學物質在乳癌發生和形成中起著重要的作用。有機氯化物的殺蟲劑和多氯聯苯等形成了「擬雌激素的物質」，已被偵測出存在於人類乳房的脂肪組織和人類乳汁當中，這些物質皆來自於食物、水、空氣的環境污染，由於它們親脂特性會在乳房脂肪中累積。除此之外，用於腋下和胸部的保養品含有一些雌激素的化學物質，這些被留在皮膚特定位置的保養品，讓乳房暴露在含雌激素的化學物質的情況下，直接由皮膚吸收。環境荷爾蒙對人體所造成的危害更是另人擔憂，因為它在體內干擾荷爾蒙的作用，使得人體荷爾蒙失調。 本報告提出證據顯示含外來的雌激素、藥用的雌激素、植物的雌激素、體內的雌激素的保養品中的化學物質在功能鍵結的交互作用下，會提升乳癌的發生率。

”Environmental hormones” can be said that the environment outside of a chemical substance. The original does not exist in the body, the body subject to external chemical substances endocrine system disruption, resulting in gene mutation and reproduction-related response to various exceptions. Many of the environment with estrogen hormone activity of chemical substances in the formation of breast cancer development and plays an important role. A range of organochlorine pesticides and polychlorinated biphenyls possess oestrogen-mimicking properties and have been measured in human breast adipose tissue and in human milk. These enter the breast from varied environmental contamination of food, water and air, and due to their lipophilic properties can accumulate in breast fat. However, it is emerging that the breast is also exposed to a range of oestrogenic chemicals applied as cosmetics to the underarm and breast area. These cosmetics are left on the skin in the appropriate area, allowing a more direct dermal absorption route for breast exposure to oestrogenic chemicals and allowing absorbed chemicals to escape systemic metabolism. This review considers evidence in support of a functional role for the combined interactions of cosmetic chemicals with environmental oestrogens, pharmacological oestrogens, phyto-oestrogens and physiological oestrogens in the rising incidence of breast cancer.