固態奈米脂質與奈米結構脂質載體製備研究與探討

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers Production of Research and Discussion

10.30001/JIES.201209.0004

黃筠茜(Yun-Chien Huang)；陳崇裕(Chon-Yu Chen)

固態奈米脂質 ； 奈米結構脂質載體 ； Solid lipid nanoparticles ； Nanostructured lipid carriers

美容科技學刊

9卷3期（2012 / 09 / 01）

37 - 53

繁體中文

近年來微膠粒技術逐漸受到重視，並廣泛被應用於各個產業，而固態奈米脂質（Solid lipid nanoparticles, SLNs）與奈米結構脂質載體（Nanostuctured Lipid Carriers, NLCs）主要都是以脂質膠體構造組成與人體相容性佳，而本研究利用超音波震盪法、高速均質／超音波法和熱高壓均質法製備固態奈米脂質（Solid lipid nanoparticles, SLNs）與奈米結構脂質載體（Nanostuctured Lipid Carriers, NLCs），搭配不同的脂質和界面活性劑，觀察每個配方的粒徑大小分布與安定性的評估分析。

In recent years, micelle technology has drawn much attention and been applied to various industries. Both solid nano-lipid (SLNs) and nanostructured lipid carriers (NLCs) consist of lipid colloidal structure and are very compatible with human body. This study employs sonication method, high-speed homogenization/ultrasound method, and high-pressure homogenization method to prepare solid nano-lipid (SLNs) and nanostructured lipid carriers (NLCs). This study also assesses and analyzes distribution of particle size and stability of each prescription by coordinating various lipid and surfactant.

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