複方精油微膠囊製備與安定性評估

Preparations and Stability Assessment of Microcapsules Encapsulated Compound Essential Oils

10.30001/JIES.201303_10(1).0004

趙玉盞(Yu-Chan Chao)；陳崇裕(Chon-Yu Chen)；吳勝豐(Sheng-Feng Wu)

海藻酸鈉 ； 幾丁聚醣 ； 複方精油 ； alginate ； Chitosan ； Compound Essential Oils

美容科技學刊

10卷1期（2013 / 03 / 01）

37 - 50

繁體中文

本實驗主要研究以海藻酸鈉、海藻酸鈉／幾丁聚醣為殼材，複方精油為蕊材之微膠囊（Microcapsules）包覆系統。本研究實驗結果顯示：1.海藻酸鈉包覆A組（A-1）複方精油製備之微膠囊於4°C之環境中，1－20天粒徑逐漸增加，30－100天則呈現下降再增高的趨勢；另於室溫環境中置放30天，粒徑會增加，至100天之粒徑則與存放4°C時漸趨近。2.海藻酸鈉／幾丁聚醣包覆A組（A-2）複方精油製備之微膠囊於4°C之環境中，1－20天粒徑逐漸下降，30－100則漸趨於穩定狀態，其PDI值較小，顯示粒子分散性集中，於室溫及4°C等不同環境中，20－30天粒徑先緩緩上升，再趨於穩定狀態；本組的粒徑變化趨勢有明顯的一致性，微膠囊穩定性較佳。3.海藻酸鈉包覆B組複方精油之微膠囊（B-1），儲存於4°C之環境中1－100天粒徑低於100 nm，分佈極為平均，其1－100天之PDI值顯示分散性集中，為單分散分佈，且穩定性極佳；另於室溫環境中置放30天，粒徑會稍微增加，至100天之粒徑則下降到與存放4°C時相近。4.海藻酸鈉／幾丁聚醣包覆B組（B-2）精油之微膠囊於4°C之環境中，粒徑隨著時間增長而呈現高低起伏狀態；於室溫環境中，20－30天粒徑快速上升，於100天內再降至與保存4°C時接近。5.海藻酸鈉／幾丁聚醣不論包覆A組（A-2）或B組（B-2）複方精油，其製備之微膠囊粒徑分佈皆相近。

The select of this experiment was to alginate, alginate/chitosan shell material, compound essential for the core Microcapsule encapsulated system. The experimental results show:1. Alginate microcapsule encapsulated compound essential oils A (A-1) in 4°C environment, 1-20 days gradually increase the size, 30-100 days show a downward again increase trend; Also at room temperature environment placement 30 days later the size larger, 100 days later the size similar and stored at 4°C.2. Alginate/Chitosan microcapsules encapsulated compound essential oils A (A-2) in 4°C environment, 1-20 days gradually smaller the size, 30-100 days show gradually stabilized, PDI value smaller show dispersion concentration focus; in room temperature and 4°C environment 20-30 days gradually increase the size again stability status; the Microcapsules (A-2) size show stability trend for apparent consistency.3. Alginate microcapsules encapsulated compound essential oils B (B-1), at 4°C environment stored 1-100 days lower than 100 nm the size, PDI value show dispersion concentration focus is good stability and monodisperse distribution; Also at room temperature environment placement 30 days later the size larger, 100 days later the size gradually smaller to similar stored at 4°C.4. Alginate/Chitosan microcapsules encapsulated compound essential oils B (B-2) in 4°C environment, grow over time show ups and downs status the size; at room temperature environment 20-30 days showfast rise. 100 days later the size gradually smaller to similar stored at 4°C.5. Alginate/Chitosan microcapsules encapsulated compound essential oils whether A (A-2) or B (B-2), the particle size distribution all to similar.

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