Risk Factors for Stroke

腦中風的危險因子

10.29688/MHJ.200707.0003

陳年(Nien Chen)；蕭正光(Zhen G. Shaw)；曹汶龍(Wen L. Cao)；李燕鳴(Yen M. Li)；鄭南成(Nan C. Zhen)；張君悌(Jun T. Chang)；陳秋美(Qiu M. Chen)

腦中風 ； 危險因子 ； 身高 ； 高密度脂蛋白 ； stroke ； risk factors ； height & HDL

明新學報

33期（2007 / 07 / 01）

47 - 53

英文

腦中風為全球十大死因之一，也是中老年人殘障的主要原因。台灣地區每十萬人中，就有六十人死於腦中風疾病，僅次於惡性腫瘤。腦中風的病因尚不完全清楚，基本上是先天遺傳和後天因素的交互影響所致。本研究的目的是檢測腦中風危險因子與不同年齡層病患的相關性。根據所獲資料之研究與分析，其結果除了確認患高血壓的人易患中風外，本研究數據顯示：1.高密度脂蛋白與腦中風似乎有負相關性；2.女性在四十歲至六十歲之間，發生腦中風的危險性與身高亦似為負相關；同時尿酸偏高也可能為腦中風的因子之一。此研究所得之資訊將有助於腦中風病因的探索與確定。明瞭腦中風發病的機制並掌控其發病的各項危險因子，當可收到早作防治此種病症之效益。

Cerebrovascular Disease (CVD) or Stroke (Cerebrovascular Accident, CVA, or Apoplexy) has been one of the leading causes of death worldwide. It is also the second most common cause of neurologic disability after Alzheimer's disease and remains the major reason of institutional placement for loss of independence among adults. The etiology and pathophysiology of CVD are complex and multifactorial. The aim of the present study is to investigate the interrelationship between some candidate risk factors and stroke incidences among different age groups. The results demonstrated and/or confirmed the associations between hypertension and stroke incidence. More significantly, the data suggested that body height, especially in females, was inversely associated with stroke incidence for individuals from age 40 to 60. High Density Lipoprotein (HDL) appeared to play a protective role in stroke. In addition, the study revealed a circumstantial association between uric acid and stroke incidence. New findings obtained regarding the risk factors for stroke incidence could facilitate the identification of individuals at increased risk of the disease. To comprehend the risk factor basis of stroke would have immediate clinical and public health benefits by guiding novel therapeutic approaches, aiding new drug discovery, and suggesting an appropriate life style for those at risk.

1. Alberts MJ(2003).Genetic epidemiology of ischemic stroke.Advances in Neurol,92,21-27.
2. Anderson CS,Carter KN,Hackett ML,Feigin V,Barber PA,BroadJB, Bonita R(2005).Trends in stroke incidence in Auckland, New Zealand, During 1981 to 2003.Stroke,36,2087-2093.
3. Arieson MJ,claus SP,Rinkel GJE,Algra A(2003).Risk factors for intracerebral hemorrhage in the general population.Stroke,34,2060-2066.
4. Carolei A,Sacco S,DeSantis F,Marini C.(2002).Epidemiology of stroke.Clin & Experimental Hypertension,24,479-483.
5. Feigin VL,Rinkel GJE,Lawes CMM(2003).Risk factors for subarachnoid hemorrhage: An updated systematic review of epidemiological studies.Stroke,34,2773-2780.
6. Goldbourt U,Tanne D.(2002).Body height is associated with decreased long-term stroke but not coronary heart disease mortality?.Stroke,33,743-748.
7. Jood K,Ladenvall P,Tjarnlund-Wolf A,LadenvallC, Andersson M,Nilsson S,Blomstrand C,Jern C.(2005).Fibrinolytic gene polymorphism and ischemic stroke.Stroke,36,2007-2081.
8. Lee TH,Hsu WC,Chen CJ(2002).Etiologic study of young ischemic stroke in Taiwan.Stroke,33,1950-1955.
9. Liu HM,Tu YK,Yip PK(1996).Evaluation of intracranial and extracranial carotid steno-occlusive diseases in Taiwan Chinese patient with MR angiography: preliminary experience.Stroke,27,650-653.
10. Morrision AC,Brown A,Kardia SL(2003).Evaluating the context-dependent effect of family history of stroke in a genome scan for Hypertension.Stroke,34,1170-1175.
11. Njolstad I,Arnesen E,Lund-Larsen D G(1996).Body height, cardiovascular risk factors, and risk of stroke in middle-aged men and women.Circulation,94,2877-2882.
12. Shearman AM,Cooper JA,Kotwonski PJ,Humphries ME,Mendelsohn ME,Housman DE,Miller GJ.(2005).Estrogen receptor alpha gene variation and the risk of stroke.Stroke,36,2281-2282.
13. Szolnoki Z,Somogyvari F,Kondacs A(2002).Evaluation of the interactions of common genetic mutations in stroke subtypes.J. Neurol,249,1391-1397.
14. Truelsen T,Bonita R(2003).Advances in ischemic stroke epidemiology.Advances in Neurology,92,1-12.
15. Wolf PA(2003).Fifty years at Framingham: Contributions to stroke epidemiology.Advances in Neurology,92,165-172.

1. 戴友榆、劉珮吟、胡益進、林柏煌(2008)。雲林縣輕度中風患者對中風復發知識、支持性環境、資訊充足度、中風復發態度及健康行爲調查研究。健康促進與衛生教育學報，30，107-132。