Nuclear Factor-Kappa B Expression with Clinicopathological Factors in Colorectal Adenocarcinoma

NF Kappa B基因於人類大腸直腸癌的表現

10.6200/TCMJ.2007.4.3.02

游伯齡(Po-Ling Yu)

Nuclear Factor Kappa B ； 免疫組織化學染色 ； nuclear factor kappa b ； immunohistochemical

北市醫學雜誌

4卷3期（2007 / 03 / 01）

212 - 218

英文

Background and Purpose: To evaluate the expression of nuclear factor kappa b (NF-κB) in patients with colorectal adenocarcinoma and the association of clinicopathological factors. Methods: Forty-six specimens resected from patients with colorectal adenocarcinoma were investigated by immunohistochemical stain against nuclear factor kappa b. The 46 specimens were divided into stain-positive and negative groups. Correlations between nuclear factor kappa b and various clinicopathological factors were studied. Results: There was a significantly increased expression of NF-κ B in cancerous colorectal epithelium in comparison with normal one statistically. (p＜0.0001) The expression of NF-κB was increased in colorectal adenocarcinoma which invaded the muscular layer of bowel wall. (p＜0.05) Conclusion: Nuclear factor kappa b expression was upregulated in human colorectal adenocarcinoma. Cancers with muscular invasion of colorectal bowel wall had high expression of NF-κB.

Background and Purpose: To evaluate the expression of nuclear factor kappa b (NF-κB) in patients with colorectal adenocarcinoma and the association of clinicopathological factors. Methods: Forty-six specimens resected from patients with colorectal adenocarcinoma were investigated by immunohistochemical stain against nuclear factor kappa b. The 46 specimens were divided into stain-positive and negative groups. Correlations between nuclear factor kappa b and various clinicopathological factors were studied. Results: There was a significantly increased expression of NF-κ B in cancerous colorectal epithelium in comparison with normal one statistically. (p＜0.0001) The expression of NF-κB was increased in colorectal adenocarcinoma which invaded the muscular layer of bowel wall. (p＜0.05) Conclusion: Nuclear factor kappa b expression was upregulated in human colorectal adenocarcinoma. Cancers with muscular invasion of colorectal bowel wall had high expression of NF-κB.