Metoclopramide引起小兒錐體外徑症候群

Metoclopramide-Induced Extrapyramidal Syndromes in Children

10.6200/TCMJ.2012.9.1.07

梁雅惠(Ya-Hui Liang)；吳淑娟(Shu-Chuan Wu)

小兒 ； metoclopramide ； 錐體外徑症狀 ； children ； metoclopramide ； EPS

北市醫學雜誌

9卷1期（2012 / 03 / 01）

78 - 83

繁體中文

Metoclopramide為中樞多巴胺（dopamine）接受體的拮抗劑，用於預防嘔吐、逆流性消化性食道炎、糖尿病引起之胃腸蠕動異常，長期或高劑量使用，或病患具高危險因子者，皆易產生錐體外徑症狀（Extrapyramidal syndromes，EPS），當EPS產生時應立即停藥並給予解藥緩解，本文為一位七個月及一位七歲大的小女孩因使用metoclopramide後產生不良反應之案例。

Metoclopramide is a CNS dopamine antagonist that is used to treat vomiting, GERD, and abnormal gastrointestinal peristalsis induced by diabetes mellitus. Long-term or high dose use of metoclopramide may easily lead to extrapyramidal syndrome (EPS), especially among those who are at high risk. If EPS occurs, physicians must halt the use of metoclopramide and then give an antidote that will relieve the symptoms. This case report describes adverse drug reactions due to metoclopramide that occurred in a seven-month old infant and in a seven-year old girl.