運動與微血管增生

Exercise and Angiogenesis

10.6127/JEPF.2005.03.02

吳明杰(Ming-Chieh Wu)；蔡櫻蘭(Ying-Lan Tsai)；陳美枝(Mei-Chih Chen)；郭家驊(Chia-Hua Kuo)

運動 ； 微血管增生 ； 血管內皮細胞生長因子 ； Exercise ； Angiogenesis ； VEGF

運動生理暨體能學報

3輯（2005 / 12 / 16）

13 - 19

繁體中文

微血管增生(angiogenesis)對於運動訓練提昇氧化能力扮演著舉足輕重的角色。肌肉組織發展出廣大的微血管網絡，肌細胞與微血管腔間的養份運送及廢物排除獲得改善，進而提昇氧化代謝能力。Prior, Yang, and Terjung(2004)指出分歧型微血管增生可能是運動訓練後微血管形成的主要方式。在分子生物的層級上，許多的生長因子與運動導致微血管增生具密切相關，包括血管內皮細胞生長因子(vascular endothelial growth factor, VEGF)、基礎纖維母細胞生長因子(basic fibroblast growth factor, bFGF)、血管生成素(angiopoietin)、轉型生長因子-β1(transforming growth factor, TGF-β1)及基質金屬蛋白酶(matrix metalloproteinases, MMPs），其中以VEGF不需其它因子的協助，可直接影響微血管增生最為重要。

Angiogenesis plays a central role in the improvement of oxidative capacity following exercise training. Expansion of the capillary network, a process termed angiogenesis, is effective at improving exchange properties between the vascular space and the intracellular volume of the fiber. Recent research has suggested that sprouting angiogenesis may be the primary way of capillary formation after exercise training. A number of important angiogenic factors were closely associated with exercise-induced angiogenesis, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin, transforming growth factor-β1 (TGF-β1), and matrix metalloproteinases (MMPs). Furthermore, VEGF appears to be a very important element in angiogenesis because VEGF has been shown to act without the other angiogenic factors.

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