题名

Exercise and Leukocyte Redistribution

并列篇名

運動與白血球再分配

DOI

10.6127/JEPF.2007.05.04

作者

李再立(Tzai-Li Li)

关键词

運動 ; 壓力激素 ; 白血球再分配 ; exercise ; stress hormones ; leukocyte redistribution

期刊名称

運動生理暨體能學報

卷期/出版年月

5輯(2006 / 12 / 07)

页次

29 - 38

内容语文

英文

中文摘要

本篇綜評旨在陳述運動如何經由激活交感神經系統(sympathetic nervous system)和丘腦下部-腦垂體-腎上腺軸(hypothalamic-pituitary-adrenal-axis)而影響白血球再分配(leukocyte redistribution)。摘要言之,長時間運動中所出現之立即性白血球增多(leukocytosis)主要肇因於較高之血漿兒茶酚胺(catecholamines)濃度,而延遲性嗜中性球增多(delayed neutrophilia)則受繼之昇高之血漿皮質固醇(cortisol)所影響。此外,生長激素(growth hormone)亦會導致循環嗜中性球增多現象。運動中補充碳水化合物有助於維持血漿葡萄糖濃度的穩定,進而促進耐力性運動表現,減緩血漿壓力激素濃度和白血球再分配之波動。

英文摘要

This review was to present an overview of the current knowledge of how exercise affects the leukocyte redistribution via stimulation of sympathetic nervous system and hypothalamic-pituitary-adrenal-axis. To summarize, the immediate leukocytosis during prolonged exercise is mainly due to elevated plasma catecholamines levels, whereas the delayed neutrophilia is from the influence of elevated plasma cortisol levels. Besides, growth hormone is also partly responsible for exercise-induced neutrophilia. However, carbohydrate supplementation during exercise is beneficial for maintenance of plasma glucose concentrations and then both improving endurance exercise performance and attenuating the elevation of plasma stress hormones and perturbation of leukocyte redistribution.

主题分类 醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 社會醫學
社會科學 > 體育學
参考文献
  1. Benschop, R. J.,Rodriguez-Feuerhahn, M.,Schedlowski, M.(1996).Catecholamine-induced leukocytosis: Early observations, current research, and future directions.Brain, Behaviour, and Immunity,10,77-91.
  2. Berczi, I.(1997).Pituitary hormones and immune function.Acta Paediatr,423,70-75.
  3. Bishop, N. C.,Blannin, A. K.,Walsh, N. P.,Gleeson, M.(2001).Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2 max.International Journal of Sports Medicine,22,226-231.
  4. Bishop, N. C.,Gleeson, M.,Nicholas, C. W.,Ali, A.(2002).Influence of carbohydrate supplementation on plasma cytokine and neutrophil degranulation responses to high intensity intermittent exercise.International Journal of Sport Nutrition and Exercise Metabolism,12,145-156.
  5. Calvano, S. E.,Barber, A. E.,Hawes, A. S.,De Riesthal, H. F.,Cole, S. M.,Lowry, S. F.(1992).Effect of combined cortisol-endotoxin administration on peripheral blood leukocyte counts and phenotype in normal humans.Archives of Surgery,127(2),181-186.
  6. Cupps, T. R.,Fauci, A. S.(1982).Corticosteroid-mediated immunoregulation in man.Immunological Review,65,133-155.
  7. Dhabhar, F. S.,Miller, A. H.,Stein, M.,McEwen, B. S.,Spencer, R. L.(1994).Diurnal and acute stress-induced changes in distribution of peripheral blood leukocyte subpopulations.Brain, Behaviour, and Immunity,8,66-79.
  8. Elenkov, I. J.,Wilder, R. L.,Chrousos, G. P.,Vizi, E. S.(2000).The sympathetic nerve-an integrative interface between two supersystems: The brain and the immune system.Pharmacological Review,52,595-638.
  9. Ernstrom, U.,Sandberg, G.(1974).Adrenaline-induced release of lymphocytes and granulocytes from the spleen.Biomedicine,21,293-296.
  10. Fauci, A. S.(1976).Mechanism of corticosteroid action on lymphocyte subpopulations.Clinical Experimental Immunology,24,54-62.
  11. Fauci, A. S.,Dale, D. C.(1975).The effect of hydrocortisone on the kinetics of normal human lymphocytes.Blood,46(2),235-243.
  12. Foster, N. K.,Martyn, J. B.,Rangno, R. E.,Hogg, J. C.,Pardy, R. L.(1986).Leukocytosis of exercise: Role of cardiac output and catecholamines.Journal of Applied Physiology,61(6),2218-2223.
  13. Fricker, P. A.,McDonald, W. A.,Gleeson, M.,Clancy, R. L.(1999).Exercise-associated hypogammaglobulinemia.Clinical Journal of Sport Medicine,9,46-49.
  14. Gannon, G.A.,Rhind, S. G.,Shek, P. N.,Shephard, R. J.(2001).Differential cell adhesion molecule expression and lymphocyte mobilisation during prolonged aerobic exercise.European Journal of Applied Physiology,84,272-282.
  15. Glaser, R.,Rabin, B.,Chesney, M.,Natelson, B.(1999).Stress induced immunomodulation: Implications for infectious diseases.JAMA,281(24),2268-2270.
  16. Gleeson, M.,Bishop, N. C.,R. J. Maughan (Ed.)(1999).Basic and applied sciences for sports medicine.Oxiford:Butterworth-Heinemann.
  17. Hansen, J. B.,Wilsgard, L.,Osterud, B.(1991).Biphasic changes in leukocytes induced by strenuous exercise.European Journal of Applied Physiology,62,157-161.
  18. Hattori, N.,Saito, T.,Yagyu, T.,Jiang, B.-H.,Kitagawa, K.,Inagaki, C.(2001).GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils.Journal of Clinical Endocrinology and Metabolism,86,4284-4291.
  19. Henson, D. A.,Nieman, D. C.,Nehlsen-Cannarella, S. L.,Fagoaga, O. R.,Shannon, M.,Bolton, M. R.(2000).Influence of carbohydrate on cytokine and phagocytic responses to 2 h of rowing.Medicine & Science in Sports & Exercise,32(8),1384-1389.
  20. Hoffman-Goets, L.(1994).Exercise, natural immunity, and tumor metastasis.Medicine & Science in Sports & Exercise,26(2),157-163.
  21. Hogg, J. C.(1987).Neutrophil kinetics and lung injury.Physiological Review,67,1249-1295.
  22. Kanaley, J. A.,Weltman, J. D.,Veldhuis, J. D.,Rogol, A. D.,Hartman, M. L.,Weldhuis, A.(1997).Human growth hormone response to repeated bouts of aerobic exercise.Journal of Applied Physiology,83(5),1756-1761.
  23. Kanaley, J. A.,Weltman, J. Y.,Pieper, K. S.,Weltman, A.,Hartman, M. L.(2001).Cortisol and growth hoemone responses to exercise at different time of day.Journal of Clinical Endocrinology and Metabolism,86,2881-2889.
  24. Kappel, M.,Hansen, M. B.,Diamant, M.,Jorgensen, J. O. L.,Gyhrs, A.,Pedersen, B. K.(1993).Effects of an acute bolus growth hormone infusion on the human immune system.Hormone and Metabolism Research,25,579-585.
  25. Kjaer, M.(1989).Epinephrine and some other hormonal responses to exercise in man: With special refence to physical training.International Journal of Sports Medicine,10,2-5.
  26. Landmann, R.(1992).Beta-adrenergic receptors in human leukocyte subpopulations.European Journal of Clinical Investigation,22,30-36.
  27. Loeper, M.,Crouzon, O.(1904).L'action de l'adrenaline sur le sang.Archery of Medicine and Experiment,16,83-104.
  28. Mackinnon, L. T.(2000).Chronic exercise training effects on immune function.Medicine & Science in Sports & Exercise,32(7),369-376.
  29. Matthews, C. E.,Ockene, I. S.,Freedson, P. S.,Rosal, M. C.,Merriam, P. A.,Hebert, J. R.(2002).Moderate to vigorous physical activity and risk of upper-respiratory tract infection.Medicine & Science in Sports & Exercise,34(8),1242-1248.
  30. McCarthy, D. A.,Dale, M. M.(1988).The leucocytosis of exercise: A review and model.Sports Medicine,6,333-363.
  31. Motulsky, H. J.,Insel, P. A.(1982).Adrenergic receptors in man. Direct identification, physiologic regulation, and clinical alterations.New England Journal of Medicine,307,18-29.
  32. Nakagawa, M.,Terashima, T.,D''yachkova, Y.,Bondy, G. P.,J.C., H.,Van Eeden, S. F.(1998).Glucocorticoid-induced granulocytosis: Contribution of marrow release and demargination of intravascular granulocytes.Circulation,98,2307-2313.
  33. Nieman, D. C.(1997).Immune response to heavy exertion.Journal of Applied Physiology,82(5),1385-1394.
  34. Nieman, D. C.,Fagoaga, O. R.,Butterworth, D. E.,Warren, B. J.,Utter, A.,Davis, J. M.(1997).Carbohydrate supplementation affects blood granulocyte and monocyte trafficking but not function after 2.5 h of running.American Journal of Clinical Nutrition,66,153-159.
  35. Nieman, D. C.,Johanssen, L. M.,Lee, J. W.,Arabatzis, K.(1990).Infectious episodes in runners before and after the Los Angeles marathon.Journal of Sports Medicine and Physical Fitness,30,316-328.
  36. Ostrowski, K.,Rohde, T.,Zacho, M.,Asp, S.,Pedersen, B. K.(1998).Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running.Journal of Physiology,508(3),949-953.
  37. Pedersen, B. K.,Bruunsgaar, H.,Klokker, M.,Kappel, M.,MacLean, D. A.,Nielsen, H. B.(1997).Exercise-induced immunomodulation-possible roles of neuroendocrine and metabolic factors.International Journal of Sports Medicine,18,2-7.
  38. Pedersen, B. K.,M. Schedlowski (Eds.),U. Tewes (Eds.)(1999).Psychoneuroimmunology: An interdisciplinary introduction.New York:Kluwer Academic/Plenum.
  39. Peters, A. M.,Allsop, P.,Stuttle, A. W.,Arnot, R. N.,Gwilliam, M.,Hall, G. M.(1992).Granulocyte margination in the human lung and its response to strenuous exercise.Clinical Science,82(2),237-244.
  40. Peters, E. M.,Goetzsche, J. M.,Grobbelaar, B.,Noakes, T. D.(1993).Vitamin c supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners.American Journal of Clinical Nutrition,57,170-174.
  41. Rabin, B. S.,Moyna, M. N.,Kusnecov, A.,Zhou, D.,Shurin, M. R.,L. Hoffman-Goets (Ed.)(1996).Exercise and immune function.Boca Raton:CRC Press.
  42. Samuels, A. J.(1951).Primary and secondary leucocyte changes following the intramusclar injection of epinephrine hydrochloride.Journal of Clinical Investigation,30,941-947.
  43. Schwartz, N. S.,Clutter, W. E.,Shah, S. D.,Cryer, P. E.(1987).Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms.Journal of Clinical Investigation,79,777-781.
  44. Smith, J. A.,Gray, A. B.,Pyne, D. B.,Baker, M. S.,Telford, R. D.,Weidemann, M. J.(1996).Moderate exercise triggers both priming and activation of neutrophil subpopulations.American Journal of Physiology,270,838-845.
  45. Smith, J. A.,Pyne, D. B.(1997).Exercise, training, and neutrophil function.Exercise Immunology Review,3,96-116.
  46. Suzuki, K.,Machida, K.(1995).Effectiveness of lower-level voluntary exercise in disease prevention of mature rats. I. Cardiovascular risk factor modification.European Journal of Applied Physiology,71,240-244.
  47. Suzuki, K.,Totsuka, M.,Nakaji, S.,Yamada, M.,Kudoh, S.,Liu, Q.(1999).Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage.Journal of Applied Physiology,87(4),1360-1367.
  48. Toft, P.,Helbo-Hansen, H. S.,Lillevang, S. T.,Rasmussen, J. W.,Christensen, N. J.(1994).Redistribution of granulocytes during adrenaline infusion and following administration of cortisol in healthy volunteers.Acta Anaesthesiology Scandivania,38(3),254-258.
  49. Toft, P.,Tonnesen, E.,Svendsen, P.,Pasmussen, J.W.(1992).Redistribution of lymphocytes after cortisol administration.APMIS,1000,154-158.
  50. Tvede, N.,Kappel, M.,Klarlund, K.,Duhn, S.,Halkjaer-Kristensen, J.,Galbo, H.(1994).Evidence that the effect of bicycle exercise on blood mononuclear cell proliferative responses and subsets in mediated by epinephrine.International Journal of Sports Medicine,15,100-104.
  51. Wira, C. R.,Sandoe, C. P.,Steele, M. G.(1990).Glucocorticoid regulation of the humoral immune system. I. In vivo effects of dexamethasone on IgA and IgA in serum and at mucosal surfaces.Journal of Immunology,144,142-146.
被引用次数
  1. Li, Tzai-Li(2008).Immunoendocrine Responses to Daily Repeated Exercise and the Influence of Carbohydrate Supplementation.運動生理暨體能學報,7,1-13.