補充Co Q10對運動員體內抗氧化效力及有氧運動表現之影響

Supplementation of Co Q10 on Antioxidant Capacity and Aerobic Exercise Performance in Athletes

10.6127/JEPF.2007.06.14

李寧遠(Ning-Yuean Lee)；鄭杏孚(Pei-Wen Wei)；衛沛文(Xing-Fu Cheng)；郭婕(Jip Kuol)；程一雄(I-Shiung Cheng)

Co Q10 ； 抗氧化效力 ； 有氧運動表現 ； 脂質過氧化物 ； Co Q10 ； antioxidant effect ； aerobic exercise performance ； lipid peroxides

運動生理暨體能學報

6輯（2007 / 08 / 15）

153 - 163

繁體中文

Purpose: this study was to examine whether supplementation of Co Q10 could lower formation of lipid peroxides, muscular damage, and aerobic exercise performance in athletes. Methods: Sixteen female soccer players were assigned to either the Co Q10 (120 mg per day) group or to the placebo group by matching their maximal oxygen uptakes (VO(subscript 2max)). Sixty minutes of endurance exercise at 65% VO(subscript 2max) followed by exercise at 90% VO(subscript 2max) until exhaustion was performed on a treadmill before and after a 4-week treatment period. The administration of either Co Q10 or placebo and the conduction of exercise tests were done double blinded. Results: there were no difference of malondialdehyde (MDA) after exercise between Co Q10 and placebo groups (p＞.05). There were also no significant difference of increased percentage in creatine kinase (CK) after exercise between Co Q10 and placebo groups (p＜.05). Conclusions: the results could not prove directly that Co Q10 supplementation might suppress the increase of lipid peroxides during exercise, and showed a trend of reduce creatine kinase, an index of muscular damage. The results indicated that four weeks Co Q10 supplementation did not affect aerobic exercise indices such as maximal heart rate, maximal oxygen consumption, respiratory exchange ratio, and time to exhaustion.

Purpose: this study was to examine whether supplementation of Co Q10 could lower formation of lipid peroxides, muscular damage, and aerobic exercise performance in athletes. Methods: Sixteen female soccer players were assigned to either the Co Q10 (120 mg per day) group or to the placebo group by matching their maximal oxygen uptakes (VO(subscript 2max)). Sixty minutes of endurance exercise at 65% VO(subscript 2max) followed by exercise at 90% VO(subscript 2max) until exhaustion was performed on a treadmill before and after a 4-week treatment period. The administration of either Co Q10 or placebo and the conduction of exercise tests were done double blinded. Results: there were no difference of malondialdehyde (MDA) after exercise between Co Q10 and placebo groups (p＞.05). There were also no significant difference of increased percentage in creatine kinase (CK) after exercise between Co Q10 and placebo groups (p＜.05). Conclusions: the results could not prove directly that Co Q10 supplementation might suppress the increase of lipid peroxides during exercise, and showed a trend of reduce creatine kinase, an index of muscular damage. The results indicated that four weeks Co Q10 supplementation did not affect aerobic exercise indices such as maximal heart rate, maximal oxygen consumption, respiratory exchange ratio, and time to exhaustion.

1. 賴紫蘭、吳慧君(2005)。不同方式輔酶Q10補充對籃球運動員有氧運動能力及運動後恢復期生理生化值之影響。大專體育學刊，7(1)，269-278。
   連結：
2. Bonetti, A.,Solito, F.,Carmosino, G.,Bargossi, A. M.,Fiorella, P. L.(2000).Effect of ubidecarenone oral treatment on aerpbic power in middle-aged trained subjects.J Sports Med Phys Fit,40(1),51-57.
3. Borg, G.(1962).Physical performance and perceived exertion.Lund, Sweden:Gleerup.
4. Braun, B.,Clarkson, P.,Freedson, P.,Kohl, R.(1991).Effect of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists.Int J Sport Nutr,1,353-365.
5. Davies, K. J. A.,Quintanilha, A. T.,Brooks, G. A.,Packer, L.(1982).Free radicals and tissue damage produced by exercise.Biochem Biophys Res Comm,107,1198-1203.
6. Ernster, L.(1984).Mechanism and regulation of mitochondrial ATP synthesis.Curr Top Cell Regul,24,313-334.
7. Faff, J.,Frankkiewicz-Jo''zko.(1997).A Effect of ubiquinone on exercise-induced lipid peroxidation in rat tissues.Eur J Appl Physiol,75,413.
8. Guerra, G.,Ballardini, E.,Lippa, F.,Oradei, A.,Littarru, G.(1987).Effect of the administration of ubiquinone in a group of young cyclists.Med Sport,40,359-364.
9. Lamb, D. R.(1984).Physiology of exercise: response & adaptation.Macmillan.
10. Leaf, D. A.,Kleinman, M. T.,Hamilton, M.,Barstow, T. J.(1997).The effect of exercise intensity on lipid peroxidation.Med Sci Sports Exer,8,1036-1039.
11. Littarru, G.,Lippa, S.,Oradei, A.,Serino, F.(1990).Coenzyme Q10: Blood levels and metabolic demand.Int J Tissue React,12,145-148.
12. Mitchell, M. K.,George, R. L.,Leonard, A. K.,Janet, L.H.,Noel, D. N.(1988).Serum creatine kinase and lactate dehydrogenase changes following an eighty kilometer race.Euro J Appli Physio,57(1),60-63.
13. Morehouse, L. E.(1972).Laboratory manual for physiology of exercise.The Mosby Company.
14. Overvad, O. K.,Diamant, B.,Holm, L.,Holmer, G.,Mortenaen, S. A.,Stender(1997).Efficacy and safety of dietary supplementation containing Co Q10.Ugeskrift for Laeger,159,7309-7315.
15. Porter, D. A.,Costill, J. J.,Zachwieja, W.J.,Fink, E.,Folkers, K.(1995).The effects of oral coenzyme Q10 on the exercise tolerance of middle-aged untrained men.Int J Sports Med,16,421-427.
16. Robert, B. C.,Dave, M.,Wilkinson, J. O.,Fallowfield, L.,Donnelly, A.(1998).Elevated serum antioxidant capacity and plasma malondiadehyde concentration in response to a simulated half-marathon run.Med Sci Sports Exer,11,1603-1607.
17. Shimomura, Y.,Suzuki, M.,Sugiyama, S.,Hanaki, Y.,Ozawa, T.(1991).Protective effect of coenzyme Q10 on exercise-induced muscular injury.Biochem Biophys Res Commun,176(1),349-355.
18. Vuorimaa, T.,Vasankari, T.,Mattila, K.,Heinonen, O.,Hakkinen, K.,Rusko, H.(1999).Serum hormone and myocellar protein recovery after intermittent runs at the velocity associated with VO2max.Eur J Appl Physiol,80(6),575-581.
19. Wells, J.,Balke, B.,Van Fossan, D.(1957).Lactic acid accumulation during work-A suggested standardization of work classification.J. Appl. Physiol,10,51-52.
20. Ylikoski, T.,Piirainen, J.,Hanninen, O.,Penttinen, J.(1997).The effect of coenzyme Q10 on the exercise performance of the cross-country skiers.Mol Aspects Med,18,283-290.
21. Zuliani, U.,Bonetti, A.,Campana, M.,Cerioli, G.,Solito, F.,Novarini, A.(1989).The influence of ubiquinone (Co Q10) on the metabolic response to work.J Sports Med Phys Fit,29,57-63.