题名

運動、自由基與抗氧化增補劑相關之探討

并列篇名

The Relationship between Physical Exercise, Free Radical and Antioxidant Supplements

DOI

10.6127/JEPF.2007.06.03

作者

莊瑞焜(Jui-Kun Chuang);謝錦城(Chin-City Hsieh)

关键词

運動 ; 自由基 ; 抗氧化增補劑 ; physical exercise ; free radical ; antioxidant supplements

期刊名称

運動生理暨體能學報

卷期/出版年月

6輯(2007 / 08 / 15)

页次

23 - 34

内容语文

繁體中文

中文摘要

活性氧物種(reactive oxygen species, ROS)是誘發體內自由基氧化壓力決定因素之一。本文首先探討激烈運動ROS之主要產生途徑與清除機制,其次比較混合維生素增補劑處方對運動氧化、抗氧化指標測試結果。指出激烈運動後部分ROS信號分子刺激所產生的運動適應,可能提高之氧化壓力適應能力、個別受試對象體內組織與細胞間存在不同程度之抗氧化劑、與不同增補劑處方介入等交互因素,來解釋受試者體內不同程度氧化與抗氧化指標變化測試結果。提供未來針對特定運動項目與強度刺激,闡述受試者體內局部或組織間ROS與抗氧化指標變化之可能交互機制參考。同時建議進一步針對傳統中草藥,發展其抗氧化與抗發炎成分在運動誘發氧化壓力之成效研究,確認其運動抗氧化增補劑之應用價值,與運動恢復之選擇利用。

英文摘要

Reactive oxygen species (ROS) as one of the decisive factors induced the internal free radicals to oxidative stress. In this review, we first investigated the main source of ROS following acute exercise and the removed mechanism, the second to analyze the research effects of mixed vitamins supplements on the marks between oxidant and antioxidant induced by physical exercise. The result revealed that the mutual factors of the adaptive process of exercise caused by the signal molecule of ROS following acute exercise, may enhance the adaptive ability to oxidative stress, the internal tissues itself with different concentration of antioxidants and the different prescription of supplements etc., to explain the different level of marks between ROS and antioxidant in individuals from other comparing researches. These factors provide the next research to expound the possible interactive mechanism between ROS and antioxidants in local or different tissues of individuals under the specific exercise and intensity stimulation. We also recommended to the further research about the test effects of antioxidant and anti-inflammation components in traditional Chinese medical herb to oxidative stress induced by physical exercise, to confirm its application value in sport antioxidant supplements and help to make use of sports recovery.

主题分类 醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 社會醫學
社會科學 > 體育學
参考文献
  1. 林學宜、林培元、徐廣明、徐台閣(2000)。不同強度運動對抗氧化酵素及丙二醛的影響。體育學報,29,137-148。
    連結:
  2. Ames, B. N.,Shigrnaga, M. K.,Hagen, T. M.(1993).Oxidant, antioxidants and the degenerative disease of aging.Proceedings of the National Academy of Science of the Unite States of American,90,7915-7922.
  3. Aoi, W.,Naito, Y.,Takanami, Y.,Kawai, Y.,Sakuma, K.,Ichikawa, H.,Yoshida, N.,Yoshikawa, T.(2004).Oxidative stress and delayed-onset muscle damage after exercise.Free Radical Biology & Medicine,37(4),480-487.
  4. Balakrishnan, S. D.,Anuradha, C. V.(1988).Exercise, depletion of antioxidants and antioxidant manipulation.Cell Biochemistry Function,16(4),269-275.
  5. Banerjee. A. K.,Mondal. A.,Chanda. D.,Chakraborti, S.(2003).Oxidant, antioxidant and physical exercise.Molecular and Cellular Biochemistry,253(1-2),307-312.
  6. Belcastro, A. N.,Arthur, G. D.,Albisser, T. A.,Raj, D. A.(1996).Heart, liver, and skeletal muscle myeloperoxidase activity during exercise.Journal of Applied Physiology,80,1331-1335.
  7. Bloomer, R. J.,Goldfarb, A. H.,Wideman, L.,McKenzie, M. J.(2006).Oxidative stress response to aerobic exercise: comparison of antioxidant supplements.Medicine and Science in Sports and Exercise,38(6),1098-1105.
  8. Bryer, S. C.,Goldfarb, A. H.(2006).Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise.International Journal of Sport Nutrition and Exercise Metabolism,16(3),270-280.
  9. Chance, B.,Sies, H.,Boveris, A.(1979).Hydroperoxide Metabolism in Mammalian Organs.Physiological Review,59,527-605.
  10. Cooper, C. E.,Vollaard, N. B.,Choueiri, T.,Wilson, M. T.(2002).Exercise, free radicals and oxidative stress.Biochemical Society Transactions,30(2),280-285.
  11. Finaud, J.,Scislowski, V.,Lac, G.,Durand, D.,Vidalin, H.,Robert, A.,Filaire, E.(2006).Antioxidant status and oxidative stress in professional rugby players: evolution throughout a season.International Journal of Sports Medicine,27(2),87-93.
  12. Goldfarb, A. H.,Bloomer, R. J.,McKenzie, M. J.(2005).Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise.Medicine and Science in Sports and Exercise,37(2),234-239.
  13. Gomez-Cabrera, M. C.,Borras, C.,Pallardo, F. V.,Sastre, J.,Ji, L. L.,Vina, J.(2005).Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats.The Journal of Physiology,567(1),113-120.
  14. Griendling, K. K.,FitzGerald, G. A.(2003).Oxidative Stress and Cardiovascular Injury. Part I: Basic Mechanisms and In Vivo Monitoring of ROS.Circulation,108,1912-1916.
  15. Groussard, C.,Rannou-Bekono, F.,Machefer, G.,Chevanne, M.,Vincent, S.,Sergent, O.,Cillard, J.,Gratas-Delamarche, A.(2003).Changes in blood lipid peroxidation markers and antioxidants after a single sprint anaerobic exercise.European Journal of Applied Physiology,89(1),14-20.
  16. Jenkins, R. R.(1988).Free radical chemistry: relationship to exercise.Sports Medicine,5(2),156-170.
  17. Jenkins, R. R.,Friedland, R.,Howald, H.(1984).The relationship of oxygen uptake to superoxide dismutase and catalase activity in human skeletal muscle.International Journal of Sports Medicine,5(1),11-14.
  18. Ji, L. L.(1999).Antioxidants and oxidative stress in exercise.Proceedings of the Society for Experimental Biology and Medicine,222,283-292.
  19. Ji, L. L.,Gomez-Cabrera, M. C.,Vina, J.(2006).Exercise and hormesis: activation of cellular antioxidant signaling pathway.Annals of the New York Academy of Sciences,1067,425-435.
  20. Ji, L. L.,Katz, A.,Fu, R.,Griffiths, M.,Spencer, M.(1993).Blood glutathione status during exercise: effect of carbohydrate supplementation.Journal of Applied Physiology,74(2),788-792.
  21. Johnson, P.(2002).Antioxidant enzyme expression in health and disease: Effects of exercise and hypertension.Comparative Biochemistry and Physiology,133,493-505.
  22. Kaminski, H. J.,Andrade, F. H.(2001).Nitric oxide: biologic effects on muscle and role in muscle disease.Neuromuscul Disorders,11,517-524.
  23. Leeuwenburgh, C.,Heinecke, J. W.(2001).Oxidative Stress amd Antioxidants in Exercuse.Current Medicinal Chemistry,8,829-838.
  24. Liu, C. C.,Huang, C. C.,Lin, W. T.,Hsieh, C. C.,Huang, S.Y.,Lin, S. J.,Yang, S. C.(2005).Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise.The British journal of nutrition,94(4),595-601.
  25. Margaritis, I.,Palazzetti, S.,Rousseau, A. S.,Richard, M. J.,Favier, A.(2003).Antioxidant supplementation and tapering exercise improve exercise-induced antioxidant response.Journal of the American College of Nutrition,22(2),147-156.
  26. Marzatico, F.,Pansarasa, O.,Bertorelli, L.,Della Valle, G.(1997).Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes.The Journal of Sports Medicine and Physical Fitness,37(4),235-239.
  27. Mastaloudis, A.,Morrow, J. D.,Hopkins, D. W.,Devaraj, S.,Traber, M. G.(2004).Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners.Free Radical Biology & Medicine,36(10),1329-1341.
  28. Misra, N.,Gupta, A. K.(2006).Effect of salinity and different nitrogen sources on the activity of antioxidant enzymes and indole alkaloid content in Catharanthus roseus seedlings.Journal of Plant Physiology,163(1),11-18.
  29. Miyazaki, H.,Oh-ishi, S.,Ookawara, T.,Kizaki, T.,Toshinai, K.,Ha, S.,Haga, S.,Ji, L. L.,Ohno, H.(2001).Strenuous endurance training in humans reduces oxidative stress following exhausting exercise.European Journal of Applied Physiology,84(1-2),1-6.
  30. Packer, L.(1997).Oxidants, antioxidant nutrients and the athlete.Journal of Sports Sciences,15,353-363.
  31. Parks, D. A.,Williams, T. K.,Beckman, J. S.(1988).Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a revaluation.American Journal of Physiology,54,827-830.
  32. Peake, J.,Wilson, G.,Hordern, M.,Suzuki, K.,Yamaya, K.,Nosaka, K.,Mackinnon, L.,Coombes, J. S.(2004).Changs in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate-and high-intensity exercise.Journal of Applied Physiology,97,612-618.
  33. Powers, S. K.,DeRuisseau, K. C.,Quindry, J.,Hamilton, K. L.(2004).Dietary antioxidants and exercise.Journal of Sports Sicence,22(1),81-94.
  34. Powers, S. K.,Hamilton, K.(1999).Antioxidants and exercise.Clinics in Sports Medicine,18(3),525-536.
  35. Powers, S. K.,Kavazis, A. N.,DeRuisseau, K. C.(2005).Mechanisms of disuse muscle atrophy: role of oxidative stress.American Journal of Physiology-Regulatory, Integrative and Comparative Physiology,288(2),337-344.
  36. Powers, S. K.,Lennon, S. L.(1999).Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle.The Proceedings of the Nutrition Society,58(4),1025-1033.
  37. Quindry, J. C.,Stone, W. L.,Broeder, C. E.(2003).The effects of acute exercise on neutrophils and plasma oxidative stress.Medicine and Science in Sports and Exercise,35,1139-1145.
  38. Radak, Z.,Pucsuk, J.,Boros, S.,Josfai, L.,Taylor, A.(2000).Changes in urine 8-hydroxydeoxyguanosine levels of super-marathon runners during a four-day race period.Life Science,66(18),1763-1767.
  39. Reckelhoff, J. F.,Fortepiani, L. A.(2004).Novel mechanisms responsible for postmenopausal hypertension.Hypertension,43,918-923.
  40. Rho, K. A.,Kim, M. K.(2006).Effects of different grape formulations on antioxidative capacity, lipid peroxidation and oxidative DNA damage in aged rats.Journal of Nutritional Science and Vitaminology,52(1),33-46.
  41. Schroder, H.,Navarro, E.,Mora, J.,Galiano, D.,Tramullas A.(2001).Effects of alpha-tocopherol, beta-carotene and ascorbic acid on oxidative, hormonal and enzymatic exercise stress markers in habitual training activity of professional basketball players.European Journal of Nutrition,40(4),178-184.
  42. Senturk, U. K.,Gunduz F.,Kuro, O.,Koçer, G.,Ozkaya, Y, G.,Yesilkaya, A.,Bor-Kucukatay, M.,Uyuklu, M.,Yalcin, O.,Baskurt, O. K.(2005).Exercise- induced oxidative stress leads hemolysis in sedentary but not trained humans.Journal of Applied Physiology,99,1434-1441.
  43. Smith, J. A.(1995).Exercise, training and red blod cell turnover.Sports Medicine,19(1),9-31.
  44. Sojdin, B.,Westing, Y. H.,Apple, F. S.(1990).Biochemical mechanisms for oxygen free radical formation during exercise.Sports Medicine,10(4),236-254.
  45. Spatz, L. (Eds),Bloom, A. D. (Eds)(1992).Biological Consequences of Oxidative Stress: Implications for Cardiovascular Disease and Carcinogenesis.New York:Oxford University Press.
  46. Stamler, J. S.,Meissner, G.(2001).Physiology of nitric oxide in skeletal muscle.Physiological Reviews,81(1),209-237.
  47. Tauler, P.,Aguilo, A.,Fuentespina, E.,Tur, J. A.,Pons, A.(2002).Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes.European Journal of Physiology,443(5-6),791-797.
  48. Tauler, P.,Aguilo, A.,Guix, P.,Jimenez, F.,Villa, G.,Tur, J. A.,Cordova, A.,Pons, A.(2005).Pre-exercise antioxidant enzyme activities determine the antioxidant enzyme erythrocyte response to exercise.Journal of Sports Sciences,23(1),5-13.
  49. Thyagarajan, A.,Jiang, J.,Hopf, A.,Adamec, J.,Sliva, D.(2006).Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion.International Journal of Molecular Medicine,18(4),657-664.
  50. Traber, M. G.(2006).Relationship of vitamin E metabolism and oxidation in exercising human subjects.The British Journal of Nutrition,1,34-37.
  51. Urso, M. L.,Clarkson, P. M.(2003).Oxidative stress, exercise, and antioxidant supplementation.Toxicology,189,41-54.
  52. Yang, H. L.,Hseu, Y. C.,Chen, J. Y.,Yech, Y. J.,Lu, F. J.,Wang, H. H.,Lin, P. S.,Wang, B. C.(2006).Antrodia camphorata in submerged culture protects low density lipoproteins against oxidative modification.The American Journal of Chinese Medicine,34(2),217-231.
  53. Yu, H. M.,Wang, B. S.,Huang, S. C.,Duh, P. D.(2006).Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage.Journal of Agricultural and Food Chemistry,54(8),3132-3138.
  54. Zhang, R.,Brennan, M. L.,Shen, Z.,MacPherson, J. C.,Schmitt, D.,Molenda, C. E.,Hazen, S. L.(2002).Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation.The Journal of Biological Chemistry,27(48),46116-46122.
  55. 謝錦城(1998)。衰竭運動對老鼠紅血球脂質過氧化物、變形性、型態學的影響。台北:行政院國家科學委員會科學技術資料中心。