题名

減量訓練對於游泳選手胰島素敏感度與脂肪激素之影響

并列篇名

Effect of Reducing Training Load on Insulin Sensitivity and Adipokines Concentration in Swimmers

DOI

10.6127/JEPF.2008.07.11

作者

陳秀華(Hsiu-Hua Chen);許東雄(Tung-Hsiung Hsu);劉德智(De-Zhi Liu);方雩(Yu Fang);陳慕聰(Mu-Tsung Chen);何國龍(Kuo-Long Ho);郭家驊(Chia-Hua Kuo)

关键词

腰圍 ; 葡萄糖耐受度 ; 胰島素敏感度 ; waist ; oral glucose tolerance test ; insulin sensitivity

期刊名称

運動生理暨體能學報

卷期/出版年月

7輯(2008 / 05 / 20)

页次

109 - 119

内容语文

繁體中文

中文摘要

研究目的:探討減量訓練對游泳選手身體組成、胰島素敏感度與脂肪激素(adipokines)之變化。研究設計:比較高強度訓練期與六個月減量訓練期對各項指標之影響。受試者:13位大學游泳選手參予本研究,年齡為20.35±0.21歲、身高為171.5±1.79、體重為68.8±1.74、身體質量指數(BMI)為23.4±0.68。測量指標:身體組成:身高、體重、BMI、腰圍、腰臀圍比(WHR);代謝指標:口服葡萄糖耐受度、胰島素反應、血脂濃度(TG, CHOL)以及皮質醇(cortisol)濃度;脂肪激素:瘦體素(leptin)、阻抗素(resistin)、腫瘤壞死因子α(TNF-α)、介白素6(interleukin 6)。結果:減量訓練期之腰圍與腰臀圍比明顯高於高強度訓練期,BMI與體重在兩時期無差異。口服葡萄糖耐受度與胰島素敏感度方面,減量訓練期較差於高強度訓練期。然而在血脂方面,減量訓練期血液三酸甘油酯呈現較高的趨勢,至於血膽固醇方面,兩訓練期無差異。在cortisol方面,減量訓練期明顯高於高強度訓練期。兩訓練期之leptin、TNF-α、interleukin 6比較後並無明顯差異,但高強度訓練期之resistin濃度明顯高於減量訓練期。結論:減量訓練對於遊泳選手,在葡萄糖吸收能力與胰島素敏感度方面已開始呈現退化的狀態,而造成此現象的原因可能與WHR及cortisol濃度的增加有關,然而除了resistin外,減量訓練並不會影響其他脂肪激素的濃度。

英文摘要

Purpose: To compare differences in body composition, insulin response and adipokines concentration under trained and detrained states. Design: Reducing training load for 6 months. Subjects: 13 college swimmers aged 20.4±0.21years, height 171.5±1.8 centimeters, weight 68.8±1.8 kilograms, BMI23.4±0.7. Measurements: Height, weight, BMI, waist, waist-to-hip ratio (WHR), oral glucose tolerance test, insulin, triglyceride, cholesterol, cortisol, leptin, resistin, TNF-α, and interleukin 6 (IL-6). Results: Waist and WHR were significantly increased with detraining. BMI and weight were not changed. Insulin levels on OGTT were significantly elevated with detraining. Triglyceride was not changed with detraining. Cortisol level was elevated, but leptin, TNF-α, and IL-6 was not changed. Resistin level was significantly lowered with detraining. Conclusion: Reduction in insulin sensitivity with detraining was association with increased WHR and cortisol concentration. Moreover, detraining did not affect adipokines secretion excepted for resistin.

主题分类 醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 社會醫學
社會科學 > 體育學
参考文献
  1. Ahren, B.(2000).Diurnal variation in circulating leptin is dependent on gender, food intake and circulating insulin in mice.Acta Physiologica Scandinavica,169,325-331.
  2. Birnbaum, M. J.(2001).Diabetes: Dialogue between muscle and fat.Nature,409,672-673.
  3. Chen, S. Y.,Chen, S. M.,Chang, W. H.,Lai, C. S.,Chen, M. C.,Chou, C. H(2006).Effect of 2-month detraining on body omposition and insulin sensitivity in young female dancers.International Journal of Obesity,30(1),40-44.
  4. Cheung, A. T., Ree, D.,Kolls, J. K.,Fuselier. J.,Coy, D. H.,Bryer, A. M.(1998).An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: Evidence for differential regulation of insulin signaling by TNF-alpha.Endocrinology,139,4928-4935.
  5. Christensen, J. O.,Svendsen, O. L.,Hassager, C.,Christiansen, C.(1998).Leptin in overweight postmenopausal women: No relationship with metabolic syndrome X or effect of exercise in addition to diet.International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity,22,195-199.
  6. Dresner, A.,Laurent, D.,Marcucci, M.,Griffin, M. E.,Dufour, S.,Cline, G. W.(1999).Effects of free fatty acids on glucose transport and IRS-1 associated phosphatidylinositol 3-kinase activity.The Journal of Clinical Investigation,103,253-259.
  7. Elias, A. N.,Pandian, M. R.,Wang, L.,Suarez, E.,James, N.,Wilson, A. F.(2000).Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise.Psychoneuroendocrinology,25,453-461.
  8. Essig, D. A.,Alderson, N. L.,Ferguson, M. A.,Bartoli, W. P.,Durstine, J. L.(2000).Delayed effects of exercise on the plasma leptin concentration.Metabolism: Clinical and Experimental,49,395-399.
  9. Fain, J. N.,Madan, A. K.,Hiler, M. L.,Cheema, P.,Bahouth, S. W.(2004).Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.Endocrinology,145,2273-2282.
  10. Febbraio, M. A.,Steensberg, A.,Starkie, R. L.,McConell, G. K.,Kingwell, B. A.(2003).Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise.Metabolism: Clinical and Experimental,52,939-944.
  11. Fischer, S.,Hanefeld, M.,Haffner, S. M.(2002).Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass.Acta Diabetologica,39,105-110.
  12. Flynn, M. G.,Costill, D. L.,Kirwan, J. P.,Mitchell, J. B.,Houmard, J. A.,Fink, W. J.(1990).Fat storage in athletes: Metabolic and hormonal responses to swimming and running.International Journal of Sports Medicine,11,433-440.
  13. Funahashi, T.,Nakamura, T.,Shimomura, I.(1999).Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity.Internal Medicine,38,202-206.
  14. Hickey, M. S.,Considine, R. V.,Israel, R. G.,Mahar, T. L.,McCammon, M. R.,Tyndall, G. L.(1996).Leptin is related to body fat content in male distance runners. American Journal of Physiology.Endocrinology and Metabolism,271,938-940.
  15. Hotamisligil, G. S.(1999).Mechanisms of TNF-alpha-induced insulin resistance.Experimental and Clinical Endocrinology & Diabetes,107,119-125.
  16. Hotamisligil, G. S.,Arner, P.,Caro, J. F.,Atkinson, R. L.,Spiegelman, B. M.(1995).Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.The Journal of Clinical Investigation,95,2409-2415.
  17. Hotamisligil, G. S.,Budavari, A.,Murray, D.,Spiegelman, B. M.(1994).Reduced tyrosine kinase activity of the insulin receptor in obesitydiabetes. Central role of tumor necrosis factor-alpha.The Journal of Clinical Investigation,94,1543-1549.
  18. Ivy, J. L.,Zderic, T. W.,Fogt, D. L.(1999).Prevention and treatment of non-insulin-dependent diabetes mellitus.Exercise and Sport Sciences Reviews,27,1-35.
  19. Jamurtas, A. Z.,Theocharis, V.,Koukoulis, G.,Stakias, N.,Fatouros, I. G.,Kouretas, D.(2006).The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males.European Journal of Applied Physiology,97(1),122-126.
  20. Janke, J.,Engeli, S.,Gorzelniak, K.,Luft, F. C.,Sharma, A. M.(2002).Resistin gene expression in human adipocytes is not related to insulin resistance.Obesity Research,10,1-5.
  21. Kern, P. A.,Ranganathan, S.,Li, C.,Wood, L.,Ranganathan, G.(2001).Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.American Journal of Physiology. Endocrinology and Metabolism,280,745-751.
  22. Kohrt, W. M.,Landt, M.,Birge, S. J.(1996).Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women.The Journal of Clinical Endocrinology and Metabolism,81,3980-3985.
  23. Kopelman, P. G.(2000).Obesity as a medical problem.Nature,404,635-643.
  24. Lais, U. M.,Osama, H.,Edward, S. H.,Sarah, L.,Cathy, M.,Catherine, J.(2003).Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance.Obesity Research,11(9),1048-1054.
  25. Matsuzawa, T.,Funahashi, T.,Nakamura, T.(1999).Molecular mechanisms of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances.Annals of the New York Academy of Sciences,892,146-154.
  26. Mendoza-Nunez, V. M.,Garcia-Sanchez, A.,Sanchez-Rodriguez, M.,Galvan-Duarte, R. E.,Fonseca-Yerena, M. E.(2002).Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia.Obesity Research,10,253-259.
  27. Nagaev, I.,Smith, U.(2001).Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.Biochemical and Biophysical Research Communications,285(2),561-564.
  28. Pi-Sunyer, F. X.(1993).Medical hazards of obesity.Annals of Internal Medicine,119,655-660.
  29. Steensberg, A.,Fischer, C. P.,Sacchetti, M.,Keller, C.,Osada, T.,Schjerling, P.(2003).Acute interleukin- 6 administration does not impair muscle glucose uptake or whole body glucose disposal in healthy humans.The Journal of Physiology,548,631-638.
  30. Steppan, C. M.,Bailey, S. T.,Bhat, S.,Brown, E. J.,Banerjee, R. R.,Wright, C. M.(2001).The hormone resistin links obesity to diabetes.Nature,409(6818),307-312.
  31. Warnotte, C.,Gilon, P.,Nenquin, M.,Henquin, J. C.(1994).Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells.Diabetes,43,703-711.