不同月經週期從事力竭運動對氧化壓力、肌肉損傷和力竭時間之影響

The Effect of Menstrual Cycle Phase on Oxidative Stress, Muscle Damage, and Exercise Performance after Exhaustive Exercise

10.6127/JEPF.2013.16.04

邱琴瑟(Chyn-Seh Chiou)；黃元圻(Yuan-Chi Huang)；田政文(Cheng-Wen Tien)；郭堉圻(Yu-Chi Kuo)

雌激素 ； 運動 ； 丙二醛 ； 肌酸激酶 ； estrogen ； high-intensity exercise ； malondialdehyde ； creatine kinase

運動生理暨體能學報

16輯（2013 / 06 / 01）

29 - 37

繁體中文

Purpose: The purpose of this study was to investigate the effect of menstrual cycle on performance, lipid peroxidation, and muscle damage after exhaustive exercise. Methods: Nine females with regular menstrual cycle participated in this research. The subjects preformed the incremental bicycle ergometer test until exhaustion at a constant pedal speed of 60 rpm with stepwise increment of 15W every minute after a warm-up at 15W for 3 min in mid follicular (MF) and mid luteal (ML) of menstrual cycle. Serum creatine kinase (CK), malondialdehyde (MDA), and superoxide dismutase (SOD) in the erythrocytes were measured before, immediately after and 24h after exercise. The VO2max, hart rate (HR), lactic acidosis (LA), and total exercise time were also recorded. Results: The levels of the CK and SOD were not significant changes before, immediately after and 24h after exercise during each phase of the menstrual cycle (p ＞ .05). However, the level of the MDA was significantly different between follicular phase and luteal phases of the menstrual cycle (12.01 ± 3.01 vs. 6.92 ± 3.05 nmol/ml, p ＜ .05), and it did not show a significant change after exercise during each phase of the menstrual cycle (p ＞ .05) via ANCOVA analysis. The VO2max, HR and LA were not changed but the exhaustion time between the mid-follicular phase and the mid-luteal phase (659.2 ± 101.7 vs. 690.7 ± 89.42 s, p ＜ .05). Conclusion: The findings of this study suggest that females may perform longer time before exhaustion, which may be due to a lower oxidative stress in mid luteal phase of menstrual cycle, but no different effects on oxidative stress and muscle damage in between were found.

Purpose: The purpose of this study was to investigate the effect of menstrual cycle on performance, lipid peroxidation, and muscle damage after exhaustive exercise. Methods: Nine females with regular menstrual cycle participated in this research. The subjects preformed the incremental bicycle ergometer test until exhaustion at a constant pedal speed of 60 rpm with stepwise increment of 15W every minute after a warm-up at 15W for 3 min in mid follicular (MF) and mid luteal (ML) of menstrual cycle. Serum creatine kinase (CK), malondialdehyde (MDA), and superoxide dismutase (SOD) in the erythrocytes were measured before, immediately after and 24h after exercise. The VO2max, hart rate (HR), lactic acidosis (LA), and total exercise time were also recorded. Results: The levels of the CK and SOD were not significant changes before, immediately after and 24h after exercise during each phase of the menstrual cycle (p ＞ .05). However, the level of the MDA was significantly different between follicular phase and luteal phases of the menstrual cycle (12.01 ± 3.01 vs. 6.92 ± 3.05 nmol/ml, p ＜ .05), and it did not show a significant change after exercise during each phase of the menstrual cycle (p ＞ .05) via ANCOVA analysis. The VO2max, HR and LA were not changed but the exhaustion time between the mid-follicular phase and the mid-luteal phase (659.2 ± 101.7 vs. 690.7 ± 89.42 s, p ＜ .05). Conclusion: The findings of this study suggest that females may perform longer time before exhaustion, which may be due to a lower oxidative stress in mid luteal phase of menstrual cycle, but no different effects on oxidative stress and muscle damage in between were found.

1. 王鶴森(2001)。月經週期對換氣閾值及運動時生理反應的影響。體育學報，31，229-238。
   連結：
2. Akova, B.,Sürmen-Gür, E.,Gür, H.,Dirican, M.,Sarandöl, E.,Küçükoglu, S.(2001).Exercise-induced oxidative stress and muscle performance in healthy women: Role of vitamin E supplementation and endogenous oestradiol.European Journal of Applied Physiology,84(1-2),141-147.
3. Behl, C.,Skutella, T.,Lezoualc, H, F.,Post, A.,Widmann, M.,Newton, C. J.(1997).Neuroprotection against oxidative stress by estrogens: Structure-activity relationship.Molecular Pharmacology,51(4),535-541.
4. Chung, S. C.,Goldfarb, A. H.,Jamurtas, A. Z.,Hegde, S. S.,Lee, J.(1999).Effect of exercise during the follicular and luteal phases on indices of oxidative stress in healthy women.Medicine and Science in Sports and Exercise,31(3),409-413.
5. Devasagayam, T.,Tilak, J.,Boloor, K.,Sane, K.,Ghaskadbi, S.,Lele, R.(2004).Free radicals and antioxidants in human health: Current status and future prospects.Journal of Association of Physicians of India,52,794-804.
6. Dikensoy, E.,Balat, O.,Pençe, S.,Balat, A.,Cekmen, M.,Yurekli, M.(2008).Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea.Journal of Obstetrics and Gynaecology Research,34(6),1049-1053.
7. Enns, D. L.,Tiidus, P. M.(2010).The influence of estrogen on skeletal muscle: Sex matters.Sports Medicine,40(1),41-58.
8. Ide, T.,Tsutsui, H.,Ohashi, N.,Hayashidani, S.,Suematsu, N.,Tsuchihashi, M.(2002).Greater oxidative stress in healthy young men compared with premenopausal women.Arteriosclerosis, Thrombosis, and Vascular Biology,22(3),438-442.
9. Joo, M. H.,Maehata, E.,Adachi, T.,Ishida, A.,Murai, F.,Mesaki, N.(2004).The relationship between exercise-induced oxidative stress and the menstrual cycle.European Journal of Applied Physiology,93(1-2),82-86.
10. Lekhi, C.,Gupta, P. H.,Singh, B.(2007).Influence of exercise on oxidant stress products in elite Indian cyclists.British Journal of Sports Medicine,41(10),691-693.
11. Lutoslawska, G.,Tkaczyk, J.,Panczenko-Kresowska, B.,Hübner-Woźniaka, E.,Skierska, E.,Gajewski, A. K.(2003).Plasma TBARS, blood GSH concentrations, and erythrocyte antioxidant enzyme activities in regularly menstruating women with ovulatory and anovulatory menstrual cycles.Clinica Chimica Acta,331(1-2),159-163.
12. Miyazaki, H.,Oh-ishi, S.,Ookawara, T.,Kizaki, T.,Toshinai, K.,Ha, S.(2001).Strenuous endurance training in humans reduces oxidative stress following exhausting exercise.European Journal of Applied Physiology,84(1-2),1-6.
13. Oosthuyse, T.,Bosch, A. N.(2010).The effect of the menstrual cycle on exercise metabolism.Sports Medicine,40(3),207-227.
14. Smekal, G.,von Duvillard, S. P.,Frigo, P.,Tegelhofer, T.,Pokan, R.,Hofmann, P.(2007).Menstrual cycle: No effect on exercise cardiorespiratory variables or blood lactate concentration.Medicine and Science in Sports and Exercise,37(7),1098-1106.
15. Stupka, N.,Lowther, S.,Chorneyko, K.,Bourgeois, J. M.,Hogben, C.,Tsrnopolsky, M. A.(2000).Gender differences in muscle inflammation after eccentric exercise.Journal of Applied Physiology,89(6),2325-2332.
16. Tauler, P.,Ferrer, M. D.,Romaguera, D.,Sureda, A.,Aguilo, A.,Tur, J.(2008).Antioxidant response and oxidative damage induced by a swimming session: Influence of gender.Journal of Sports Sciences,26(12),1303-1311.
17. Thompson, H. S.,Scordilis, S. P.,De Souza, M. J.(2006).Serum creatine kinase activity varies with ovulatory status in regularly exercising, premenopausal women.Hormone Research,65(3),151-158.
18. 林鉅勝、唐憶淨、黃曉峰、劉丕華(2005)。女性月經週期及實用避孕方法。基層醫學，20(5)，124-129。
19. 陳惠英、顏國欽(1998)。自由基、抗氧化防禦與人體健康。營養學會雜誌，23(1)，105-121。