3D列印多孔性Ti6Al4V之真空鍍膜與生物相容性檢測

Three-Dimensional-Printed Porous Titanium Alloys for Vacuum Coating and Biocompatibility Testing

賴峯民(FENG-MIN LAI)；巫佩軒(PEI-XUAN WU)；楊馥瑄(FU-HSUAN YANG)

多孔性 ； 3D列印 ； 羥基磷灰石 ； 真空鍍膜 ； 附著力 ； 薄膜 ； 生物相容性試驗 ； 3D printing ； porous ； HA ； vacuum coating ； adhesion ； thin film ； biocompatibility

科學與工程技術期刊

19卷1期（2023 / 03 / 01）

55 - 62

繁體中文;英文

因Ti6Al4V材料的優異特性，是植入材微創手術中重要的材料之一，但Ti6Al4V植入材本身由於楊氏係數過高（高達100 GPa）和正常人骨（15～20 GPa）差異甚多，容易產生應力遮蔽效應，因此使用3D列印多孔性結構可降低植入材的楊氏係數，且已符合人骨的楊氏係數相似的優點。本論文發展多孔性Ti6Al4V試片的真空鍍膜技術，研究主題為在3D列印多孔性Ti6Al4V試片表面鍍膜羥基磷灰石（Ca_(10)(PO_4)_6(OH)_2，簡稱HA）單層，再進行掃描式電子顯微鏡、附著力、抑菌及生物相容性等試驗，可以找出最佳鍍膜參數，並符合無細胞毒性要求。本論文中發現3D列印多孔性Ti6Al4V試片之羥基磷灰石以150 W鍍膜60 min的試片是無細胞毒性，其5天後細胞存活率為95.6%，而且抑菌效果最好，所以在150 W鍍膜60 min是最佳鍍膜參數。

Titanium alloy materials are ideal for use in implants; however, their high Young's coefficient of up to 100 GPa makes them more vulnerable to the effects of stress shielding compared with normal human bone, which has a Young's coefficient of 25-30 GPa. The Young's coefficient of titanium alloy materials can be reduced using three-dimensional（3D）-printed porous structures. In this study, 3D-printed porous titanium alloy specimens were vacuum coated with single-layer films of hydroxyapatite (Ca_(10)(PO_4)_6(OH)_2, HA). To determine the optimal coating parameters and assess cytotoxicity, the specimens were subjected to structural equation modeling, adhesion, antibacterial, and biocompatibility tests. The specimens exhibited no cytotoxicity at a power output of 50 watts for 1 hour, a cell survival rate of 91.8% after 5 days, and the best antibacterial effect at a vacuum coating power of 150 watts for 1 hour.

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