重複透顱磁刺激術在思覺失調症病人認知功能障礙的臨床應用

The Role of Repetitive Transcranial Magnetic Stimulation in the Treatment of Cognitive Impairment in Patients with Schizophrenia

10.6530/YYN.201907_13(2).0002

闕菁儀(Ching-Yi Chueh)；陳志誠(Chih-Cheng Chen)；吳永富(Yung-Fu Wu)

思覺失調症 ； 認知功能 ； 魏氏成人智力量表 ； 重複透顱磁刺激術 ； schizophrenia ； cognitive impairment ； Wechsler Adult Intelligence Scale-fourth edition ； WAIS-IV ； repetitive transcranial magnetic stimulation ； rTMS

源遠護理

13卷2期（2019 / 07 / 01）

9 - 13

繁體中文

認知功能的變化，被認為是影響思覺失調症病程的核心關鍵。相較於健康族群，認知功能的變化更能夠精確的評估思覺失調症在神經功能上的改變。病人的認知功能損害，可能源於疾病發生初期對於神經功能系統的影響。這樣的影響即便是在病人病況穩定時，仍然是持續的。神經認知功能的改變可能影響後續的生活品質、社會功能及社區復健成果，意味著改善或維持病人認知功能是很重要的。近年來，非藥物的介入方式對於病人認知功能改善的研究與日俱增，其中重複透顱磁刺激術的應用受到一定的關注，期望能在病人認知功能的改善提供可能的治療選擇。

According to the Wechsler Adult Intelligence Scale-fourth edition, patients with schizophrenia (SCZ) had poorer neurocognitive function compare to the general population. Clinical observations of cognitive impairment provide evidence that disturbed neuroplasticity in the pathophysiology of SCZ includes alterations in neurotransmitter systems and cortical connectivity. Repetitive transcranial magnetic stimulation (rTMS) is a safe and widely used non-invasive neuroscientific tool to investigate a variety of neurophysiological processes, including neuroplasticity. The therapeutic potential of rTMS in SCZ by stimulating and regulating the cortical function of the brain is beginning to show effects, but will require further study involving different trains of TMS pulses with various frequencies and intensities in the future.

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