Study of the Effect of Hydro-Ethanolic Extract of Commiphora africana (Stem-bark) on Inflammation and Pain in Rodents

I. Ezekiel；M.A. Mabrouk；J.O. Ayo

Analgesic ； anti-inflammatory ； Commiphora Africana ； phytochemical screening

Asian Journal of Medical Sciences

2卷3期（2010 / 06 / 25）

81 - 84

英文

Inflammatory response of living bodies is a protective mechanism against infected organisms. The aim of this study was to evaluate the effect of hydro-ethanolic extract of Commiphora africana (stem-bark) on inflammation and pain. The anti-inflammatory activity was investigated using the rat paw edema model. The analgesic activity was studied using the acetic acid induced writhings in mice. The results showed that the hydro-ethanolic (stem-bark) extract of Commiphora africana possess significant (p＜0.05) anti-inflmmatory effect and inhibit abdominal constriction caused by acetic acid in mice. The results of the preliminary phytochemical screening of Commiphora africana (stem bark) extract revealed the presence of flavonoids, tannin, anthraquinone, cardiac glycosides, triterpenoids, saponins, alkaloids and reducing sugars. The LD50 was calculated as 3708.7mg/kg in rats and 471.2mg/kg in mice. It was concluded that the plant is or may be a very good source of analgesic.