紙片電噴灑質譜法的特性與其作為快速篩選尿液中氯安非他命之研究

Rapid Screening and Determination of Chloroamphetamines in Urine by a Paper Spray-Mass Spectrometry

10.6134/tjfm.2013.0502.03

陳昕楷(Hsin-Kai Chen)；李珣(Hsun Lee)；張智勝(Chih-Sheng Jhang)；陳姵君(Pei-Chun Chen)；柳如宗(Ju-Tsung Liu)；林震煌(Cheng-Huang Lin)

紙片電噴灑質譜法 ； 快速篩選 ； 尿液 ； 氯安非他命 ； Paper spray ； Rapid screening ； Urine ； Amphetamines

台灣法醫學誌

5卷2期（2013 / 12 / 01）

16 - 23

繁體中文

本文介紹紙片筆尖協助－紙片電噴灑質譜的特性與其作為快速篩選尿液中氯安非他命之研究。實驗結果發現，紙片尖端的角度為15度時，高壓電為三千伏特時，紙片尖端與質譜入口的最佳距離為7.7 mm。此條件下可得最佳偵測極限。當o-，m-，p-氯安非他命及o-，m-，p-氟安非他命為測試樣品時，偵測極限可達0.1 μg/mL。本研究亦使用傳統的快速篩選質譜法，包括了大氣基質輔助雷射脫附游離質譜法與電噴灑輔助雷射脫附游離法。實驗結果發現紙片電噴灑法不僅在靈敏度高出其他兩種方法，而且使用的設備簡單，完全不需要較昂貴的雷射等設備。

A method for the rapid screening and determination of amphetamine-type designer drugs in urine by a novel nibassisted paper spray-mass spectrometry (NAPS-MS) procedure is described. When a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm. Under optimized conditions, the limit of detections for amphetamine derivatives (model samples: o-, m-, p-chloro- and o-, m-, p-fluoro-amphetamines, respectively) were determined to 0.1 μg/mL by the NAPS-MS method. This method is easier and has a higher sensitivity than similar methodologies, including atmospheric pressure/matrix-assisted laser desorption ionization mass spectrometry and electrospray-assisted laser desorption ionization/mass spectrometry.

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