Long-Term Behavioral Consequences of Prenatal Binge Toluene Exposure in Adolescent Rats

10.4303/jdar/235841

C. López-Rubalcava；Chávez-Alvarez；A. G. Huerta-Rivas；N. Páez-Martínez；S. E. Bowen；S. L. Cruz

inhalants ； solvents ； toluene ； prenatal exposure ； adolescence ； sensitization

Journal of Drug and Alcohol Research

3期（2014 / 12 / 01）

i1 - 9

英文

The continued abuse of inhaled organic solvents, especially among women of childbearing age, raises the risk of long-term behavioral effects of maternal toluene abuse. In this study, the effects of short-term exposures to high toluene concentrations (i.e., ＂binges＂) were tested in independent groups of adolescent rats with different toluene treatments: (a) acute: 30-day-old animals exposed for 30 min to air (A) or 6,000ppm toluene (T); (b) prenatal and postnatal: rats exposed to T or A from gestation days 8-20 and re-exposed to T or A from postnatal day (PN) 22 to PN30 (A/A, T/A, A/T, and T/T, resp.). On PN30, animals were evaluated in different tests. Postnatal toluene exposure produced anxiolytic-like effects in the burying behavior test, and the T/T group received the highest number of electrical shocks. Antinociception was observed in the T, A/T, and T/T groups in the hotplate test. All toluene treatments impaired short-term memory in the object recognition test, but only postnatal exposure impaired long-term memory in the passive avoidance test. Sensitization occurred in the T/T group in locomotor activity. These results indicate that prenatal exposure to a concentration of toluene that does not produce evident malformations can modify behavioral toluene's effects in adolescent rats.