談坊間市售血竭的種類與生物活性分析

Evaluation and Biological Activity Assay of Commercially Available Dragon Blood on the Traditional Chinese Medicine Market

陸乃甄(Nai-Chen Lu)；何宗融(Tsung-Jung Ho)；林明德(Ming-Der Lin)；Preethi Krishnaraj；賴尚志(Shang-Chih Lai)；陳灝平(Hao-Ping Chen)

血竭 ； 血竭素 ； 血竭素高氯酸鹽 ； 麒麟竭 ； Dragon blood ； dracorhodin ； dracorhodin perchlorate ； Daemonorops draco

北台灣中醫醫學雜誌

11卷1期（2019 / 03 / 01）

1 - 11

繁體中文

血竭在中醫藥界的使用源遠流長，除了傳統的方劑，目前在臨床上也使用於化膿性傷口、糖尿病足傷口與褥瘡。血竭是提取自植物的暗紅色樹脂。在近千年的漫長使用歷史中，多種不同來源的植物樹脂，皆被統稱之為血竭（dragon blood）。本文首先對以上的各種植物，做一介紹。目前的藥典，以產自東南亞棕櫚科黃藤屬的植物麒麟竭（Daemonorops draco）為正品。血竭的品質傳統上是以HPLC來檢定，血竭素（dracorhodin）的含量需大於1%。我們以斑馬魚的胚胎為模式，發現血竭素可以刺激其腸下靜脈血管的出芽新生。讓我們對中醫古書上『活血化瘀』這句話，有了更進一步的了解。也就是說，『血竭』可能在傷口處，藉由刺激微血管的網絡更加綿密，促進了傷口癒合。這個斑馬魚胚胎的『血竭』生物活性檢測平台，可以彌補現在HPLC檢驗方法的不足。

Dragon blood has been used in traditional Chinese medicine for thousand years. Except recipes in ancient Chinese medical books, it is also used in the treatment for suppurative wounds, diabetic foot ulcer, and bedsores nowadays. Dragon blood is deep-red resin isolated from several entirely different plants. Only dragon blood from Southeast Asia palm tree, Daemonorops draco, is considered authentic, as described in traditional Chinese medicine pharmacopeia. Moreover, the content of dracorhodin determined by HPLC should be higher than 1%. A zebrafish embryo-based platform was recently established in our groups. The in vivo angiogenic activity of dracorhodin on zebrafish sub-intestinal vein (SIV) development was first shown. Because angiogenesis is an important process in wound healing, these results provide scientific evidence of dragon blood’s wound healing activity. From the aspect of examination and quality control of commercial dragon blood products, this activity assay method can complement the current HPLC-based methods.

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