臺灣臨床常用青草藥治療代謝性肝病之機轉探討

The Mechanism Study of Taiwanese Herbs Clinically Used in Metabolic-Associated Fatty Liver Disease Treatment

劉奕德(Yi-Te Liu)；吳炫璋(Hsien-Chang Wu)；賴尚志(Shang-Chih Lai)

代謝性肝病 ； 非酒精性脂肪肝 ； 青草藥 ； MAFLD ； NAFLD ； herbs

北台灣中醫醫學雜誌

15卷1期（2023 / 03 / 01）

1 - 23

繁體中文;英文

隨著飲食習慣的改變，代謝性相關疾病日趨嚴重。其中，非酒精性脂肪肝顯然已成為不可忽視的慢性疾病。脂肪肝的危險性在於，可能造成肝臟產生良性脂肪變性，進而導致為肝炎，而最後演變為肝硬化和肝細胞癌。本文以文獻整理的方式，先歸納出慢性肝炎在中醫是如何辨證論治並加以分類，作為臨床方證對應的參考依據。並經由整理市售的青草茶及青草藥單方濃縮製劑，從中挑選出六種可用來輔助治療代謝性肝病的民間青草藥，包含：甜珠草、黃花蜜菜、咸豐草、白鶴靈芝、大本七層塔及小本七層塔，上述的青草藥除了累積大量的民間使用經驗，也透過細胞、動物實驗及活性物質成分分析等現代藥理研究分析，預期可作為中醫師在臨床治療可加減變化的處方依據。雖然代謝性肝病在初期無明顯的病徵，但透過現代醫學儀器的輔助，可以為臨床診斷提供更多的線索，若搭配中西醫的研究進行診治，加上青草藥的輔助治療，以提高方藥的臨床療效，希冀本文可以做為現代中醫師在治療慢性肝病的參考依據，並使中醫在治療代謝性肝病達到更佳的療效。

With the change of dietary habits, metabolic disorders are getting worse. In recent years, non-alcoholic fatty liver disease (NAFLD) are becoming a growing challenge for public health. The danger of fatty liver is that it may cause steatosis in the liver, which may lead to hepatitis and eventually to cirrhosis and hepatocellular carcinoma. In this article, by organizing the literature, the classification of chronic hepatitis traditional Chinese medicine is first sorted out, and it turns the reference into the treatment of prescriptions. By the collection of commercially herbal concentrates, six kinds of folk herbal medicines used for the treatment of metabolic-associated fatty liver disease (MAFLD) are including Scoparia dulcis, Wedelia chinensis, Bidens Pilosa, Rhinacanthus nasutus, Ocimum gratissimum and Salvia plebeian. These herbs have accumulated a lot of clinical experience, and have also been analyzed through modern pharmacological research such as cell and animal experiments and active chemical composition studies. It is expected that they can be used as alternatives for Chinese medical practitioner to change formula in clinical treatment. Although MAFLD has no obvious symptoms in the early stage, the assistance of medical instruments can provide more clues for clinical diagnosis. By the cooperation of traditional Chinese medicine and modern medicine, these folk herbal medicines can be used as more powerful adjuvant therapy for clinical efficacy.

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