THE EFFECT OF INONOTUS OBLIQUUS EXTRACTS IN ALLOXAN-INDUCED DIABETIC RATS

10.6338/JDA.202406_19(2).0002

Nyamsurendejid D (Nyamsurendejid Delgersaikhan)；Shine-Od D；Enkhdelger M；Suvd B；Dorjjagdag G；Purevsuren KH；Enebish S；Amgalanbaatar D；Dolgorsuren A；Avirmed A

Inonotus Obliquus ； Diabetes ； Alloxan ； Langerhans Islet ； Traditional Medicine

Journal of Data Analysis

19卷2期（2024 / 06 / 01）

5 - 15

英文

We aimed to investigate the morphological changes and clinical chemistry panel of alloxan-induced diabetic rats for the treatment groups of ethanol or aqueous extracts of Mongolian natural Inonotus obliquus. Wistar albino rats (n = 80) were randomly assigned into four groups: 1. Healthy control group, 2. Untreated diabetic group, 3. Diabetic group treated with Inonotus obliquus (500 mg/kg per day) water extract, 4. Diabetic group with Inonotus obliquus (500 mg/kg per day) ethanol extract. Diabetes was induced by alloxan 150 mg/kg (i.p. single injection) in the diabetic groups. Both water and ethanol extract of Inonotus obliquus reduced the blood glucose level of diabetes at 48 h after treatment. Histologic and morphology examinations showed that water extracts of Inonotus obliquus alleviated the damage to pancreas tissues in alloxan diabetic rats. We postulate that simple ethanol and water extracts of natural Mongolian Inonotus obliquus have an antihyperglycemic effect that enhances islet cell function in alloxan-induced diabetic rats. The extracts of Mongolian natural Inonotus obliquus are easily producible at low cost and further should be explored as a hypoglycemic dietary supplement or potential candidate for promising antihyperglycemic agent.