Iodination of Proteins in Hair Illustrated by Post-Therapy I-131 Whole-Body Scanning

碘-131全身掃描影像所呈現之蛋白質碘化反應

10.6332/ANMMI.3001.005

劉芝庭(Chih-Ting Liu)；林家揚(Chia-Yang Lin)；朱秀蘭(Hsiu-Lan Chu)；丁慧枝(Hueisch-Jy Ding)；蔡亦欣(I-Hsin Tsai)；莊雅雯(Ya-Wen Chuang)

histidine I-131 whole-body scan ； protein iodination ； radioactive contamination ； tyrosine ； 組氨酸 ； 碘-131全身掃描 ； 蛋白質碘化反應 ； 放射性汙染 ； 酪氨酸

核子醫學暨分子影像雜誌

30卷1期（2017 / 03 / 01）

30 - 33

英文

We present a case with I-131 whole-body scanning after I-131 radioablative treatment. I-131 whole-body scan was obtained 5 and 8 days after I-131 radioablative treatment. Intense I-131 accumulation above the right shoulder represented radioactive physiologic saliva contamination over the patient's hair due to drooling during sleep. The radioactive contamination over the patient's hair could not be wiped off because I-131 was bonded into tyrosine and histidine configuration, which are major amino acids responsible for hair.

我們討論一個大劑量碘-131治療之後進行碘-131全身掃描的案例。在碘-131治療後的第五及第八天進行碘-131全身掃描。發現在病患右肩上有強烈的碘-131聚積，此為病患在睡覺時流口水汙染到頭髮，導致放射性汙染聚積在頭髮。因碘-131與頭髮成分中的酪氨酸及組氨酸鍵結，造成此放射性汙染並無法因清洗而被清除或減少。