Cerebral Perfusion Change Analyzed by Easy Z-Score Imaging System and Establishing Diagnosis of Kleine-Levin Syndrome

以eZIS分析腦部灌流變化可用來診斷克萊恩－萊文症候群

10.6332/ANMMI.201909_32(3).0003

吳俊昌(Jiun-Chang Wu)；林谷鴻(Ku-Hung Lin)；楊容欣(Rong-Hsin Yang)；陳儀敏(I-Ming Chen)；曹勤和(Chin-Ho Tsao)

cerebral perfusion ； eZIS ； Kleine-Levin syndrome ； sleeping beauty syndrome ； SPECT ； 腦部灌流 ； eZIS ； 克萊恩－萊文症候群 ； 睡美人病 ； 單光子斷層掃瞄

核子醫學暨分子影像雜誌

32卷3期（2019 / 09 / 01）

139 - 144

英文

Kleine-Levin syndrome (KLS), also known as sleeping beauty syndrome, is a rare, remittent-relapsing disease mostly affecting male adolescents. The syndrome is characterized by episodes of hypersomnia of 1 to several weeks, plus cognitive, behavioral, and psychiatric disorders. We presented a case of a 17-year-old girl, who suffered from intermittent consciousness disturbance for 2 years and was suspected to have KLS. Most neuroimages, such as magnetic resonance imaging and electroencephalography showed negative findings. Tc-99m-ethyl cysteinate dimer brain perfusion single-photon emission computed tomography study revealed mild hypoperfusion in the bilateral thalami, basal ganglia, and left occipital lobe. The easy Z-score imaging system study showed prominent decreased perfusion in these areas and the diagnosis of KLS was established.

克萊恩－萊文症候群又被稱作睡美人病，是一種罕見又易復發的疾病，主要發生在青少年。其症狀包括1週以上的嗜睡現象，以及認知、行為與精神上的異常。這篇研究中我們報告1位17歲女性伴隨有2年間斷性的意識異常，且最後被診斷為克萊恩－萊文症候群。大部分的神經影像，比如核磁共振與腦波檢查均為陰性。鎝99m-ECD腦部灌流單光子斷層掃瞄檢查發現在雙側視丘與左側枕葉有輕度灌流下降的現象。進一步以easy Z-score imaging system（eZIS）分析可見在上述區域有明確的血流下降，因而建立克萊恩－萊文症候群的診斷。