工作型態對電子業勞工體內氧化壓力指標影響

The Impact of Work Patterns on the Levels of Oxidative Stress Biomarkers in Workers of the Electronics Industry

陳鑫昌(Hsin-Chang Chen)；方慈聲(Tzu-Sheng Fang)；李貞嫺(Chen-Hsien Lee)

電子零組件製造業 ； 活性氧物種 ； 8-羥基去氧鳥糞嘌呤 ； 丙二醛 ； Electronic parts and components manufacturing industry ； reactive oxygen species ； 8-hydroxy-2-deoxyguanosine ； malondialdehyde

勞動及職業安全衛生研究季刊

30卷2期（2022 / 06 / 20）

61 - 76

繁體中文

電子零組件製造業高競爭力工作易使勞工產生工作壓力、飲食不正常及熬夜焦慮，致體內產生較多活性氧物種造成氧化壓力傷害並可能產生職業傷害。為了解工作型態對勞工體內氧化壓力指標影響，本研究招募國內三家電子零組件製造廠，利用職業壓力量表問卷及過勞量表問卷納入94位壓力組及30位對照組參與者，進行問卷調查、血液及尿液檢體採集，探討氧化壓力指標與問卷資料相關性分析，並提出緩解策略。結果顯示A廠壓力組參與者主要為產線製程區勞工，其對照組參與者主要為辦公行政人員，兩組間之工作型態具顯著差異（p-value=0.026），B廠或C廠兩組間參與者勞工工作型態則無顯著差異。分析血液及尿液氧化壓力指標，A廠及B廠壓力組參與者勞工尿液8-羥基去氧鳥糞嘌呤濃度在下班後均顯著增加（A廠p-value=0.001；B廠p-value=0.004）；而其對照組及C廠兩組內參與者下班後尿液8-羥基去氧鳥糞嘌呤濃度則無差異。輪班工作與飲酒及喝咖啡習慣相關，A廠觀察到喝咖啡可能導致體內脂質過氧化指標丙二醛升高，呈現顯著相關（p-value=0.001）。

Stress during labor in the workplace of the electronic parts and components manufacturing industry is high, and excessive labor or long-term high-intensity workload leads to fatigue and diseases, caused by the oxidative stress damage from the generation of excess reactive oxygen species (ROS) in the body. To realize the impact of work patterns on the ROS biomarkers in workers of this industry, the scales of occupational stress and excessive labor were applied to recruit respective 94 and 30 participants for the high-pressure and control groups from three plants. The questionnaire and the collection of blood and urine samples of these participants were required. The urinary and plasma ROS biomarkers, i.e. 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), respectively, were evaluated to discuss the correlation between results of the questionnaire and ROS biomarkers and to propose the strategies to mitigate the adverse effects of ROS. Preliminary results indicated the working area of participants in Plant-A of the high-pressure group, majorly from the manufacturing process area, was different from that of the control group (p-value = 0.026), but this phenomenon was not observed in Plant-B and Plant-C. The concentrations of 8-OHdG in post-shift urine of high-pressure groups from Plant-A and Plant-B were also increased with p-values of 0.001 and 0.004, respectively, and those in the control groups of Plant-A and Plant-B, and all subjects from Plant-C were not significantly changed. The pattern of shift work associated with alcohol and coffee consumption, and intake of coffee would increase the level of plasma MDA (p-value = 0.001).

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