题名

兒童顱內生殖細胞瘤

DOI

10.6666/ClinMed.2016.78.4.003

作者

陳儒廷

关键词

生殖細胞瘤(germ cell tumors) ； 小兒(pediatric) ； 腦瘤(brain neoplasm)

期刊名称

臨床醫學月刊

卷期/出版年月

78卷4期（2016 / 10 / 28）

页次

194 - 198

内容语文

繁體中文
中文摘要

兒童顱內生殖細胞瘤(germ cell tumors, GCTs)在西方國家約占所有原發性腦瘤的3%左右，然而在東亞國家如日本、臺灣約占11%-15%，可見此病在東亞獲得的重視度應該較西方高。此病平均好發年紀為10-12歲，男童略多，好發部位為松果體區、上蝶鞍部位及基底神經核部位，常見的臨床症狀與腫瘤位置有密切相關：松果體區的腫瘤常有頭痛、噁心、嘔吐的急性顱內壓增高症狀；上蝶鞍部位的腫瘤常伴隨有中樞性尿崩症或腦下垂體功能低下；基底神經核部位的腫瘤則常造成肢體運動障礙。診斷此病常常需要配合臨床症狀、腫瘤標記物及影像學檢查，很多時候甚至需要手術切片來獲得證實。治療方式及預後因組織學型態不同而有差異，胚細胞瘤(germinoma)對於放射線很敏感，單純使用放射線治療即可達到五年存活率＞90%。非胚細胞瘤生殖細胞瘤(NGGCTs)則通常需要配合手術、化學治療加上放射線治療，五年存活率約為50%-71%。
主题分类 醫藥衛生 > 基礎醫學
醫藥衛生 > 社會醫學
参考文献
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