非侵蝕性食道逆流疾病

10.6666/ClinMed.2017.79.1.007

董宥汝；羅景全

侵蝕性逆流疾病(nonerosive reflux disease, NERD) ； 侵蝕性逆流疾病或侵蝕性食道炎(erosive reflux disease, erosive esophagitis, EE) ； 胃食道逆流(gastroesophageal reflux disease, GERD) ； 功能性心灼熱(functional heartburn)

臨床醫學月刊

79卷1期（2017 / 01 / 27）

32 - 38

繁體中文

非侵蝕性食道逆流疾病(nonerosive reflux disease, NERD)是胃食道逆流(gastroesophageal reflux disease, GERD)中最常見的表現型，這些病人有胃酸逆流的症狀，但在內視鏡診查中並未有黏膜受損的現象。這些NERD患者從病生理角度來看有許多不同成因，且可藉由電阻抗合併酸鹼值監測(24h impedance-pH testing)將NERD病人區分為過多胃酸分泌及食道過度敏感兩類，此外也可以用於檢查功能性心灼熱(functional heartburn) 的病人。NERD症狀產生機轉目前仍未知，但可能和非肉眼可見的食道炎及擴大的食道細胞間隙有關。質子幫浦抑制劑(proton pump inhibitor, PPI)對過多酸分泌引起的NERD有效果。至於功能性心灼熱患者，則需用到疼痛控制藥物。

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