精準的導引系統，在腫瘤內部引爆核彈正子攝影在硼中子捕獲治療扮演的角色

10.6666/ClinMed.2017.80.6.127

林可瀚；陳一瑋；顏上惠；黃文盛

硼中子捕獲治療(boron neutron capture therapy, BNCT) ； FBPA ； T/N ； acetate

臨床醫學月刊

80卷6期（2017 / 12 / 29）

698 - 701

繁體中文

硼中子捕獲治療(boron neutron capture therapy, BNCT)是一種細胞內的『標靶粒子放射治療』，就像是在腫瘤內部埋入核彈，引爆摧毀腫瘤，對週邊組織傷害極微。BNCT的成功與否取決於腫瘤攝取足夠量的硼-10藥物。含硼藥物的腫瘤與正常組織的濃度比要達到3：1以上，才能達到理想的治療效果。在治療之前，需要透過全身或腦部正子攝影檢查，篩選出適合治療的患者。接下來再進行特殊標定的^(18)FBPA評估含硼藥物在腫瘤與正常組織分布的狀況。醫師可透過18FBPA的結果評估腫瘤/正常組織吸收比率與計算治療劑量。在BNCT各個階段，正子攝影扮演的角色不僅僅是敵情偵測雷達，用來偵測腫瘤的部位與轉移。更是精密的導引系統，讓醫師能夠正確的擬定治療計畫，完成治療腫瘤的終極目標。

1. 臺灣中子捕獲治療研究學會，TSNCT
2. Barth, RF,Coderre, JA,Vicente, MG(2005).Boron neutron capture therapy of cancer: current status and future prospects.Clin Cancer Res,11,3987-4002.
3. Liu, RS,Chang, CP,Chu, LS(2006).PET imaging of brain astrocytoma with 1-11C-acetate.Eur J Nucl Med Mol Imaging,33,420-427.
4. Liu, RS,Chang, CP,Guo, WY(2010).1-11C-acetate versus 18F-FDG PET in detection of meningioma and monitoring the effect of gamma-knife radiosurgery.J Nucl Med,51,883-891.
5. Shimosegawa, E,Isohashi, K,Naka, S(2016).Assessment of 10B concentration in boron neutron capture therapy: potential of image-guided therapy using 18FBPA PET.Ann Nucl Med,30,749-755.
6. Tsuchida, T,Takeuchi, H,Okazawa, H(2008).Grading of brain glioma with 1-11C-acetate PET: comparison with 18F-FDG PET.Nucl Med Biol,35,171-176.
7. Wang, LW,Chen, YW,Ho, CY(2016).Fractionated Boron Neutron Capture Therapy in Locally Recurrent Head and Neck Cancer: A Prospective Phase I/II Trial.Int J Radiat Oncol Biol Phys,95,396-403.
8. Wang, LW,Wang, SJ,Chu, PY(2011).BNCT for locally recurrent head and neck cancer: Preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor.Appl Radiat Isot,69,1803-1806.