慢性阻塞性肺病的發炎反應與急性發作之關係

10.6666/ClinMed.201803_81(3).0024

蕭逸函；彭殿王

慢性阻塞性肺病(chronic obstructive pulmonary disease, COPD) ； 氣道發炎(airway inflammation) ； 急性發作(acute exacerbation)

臨床醫學月刊

81卷3期（2018 / 03 / 30）

128 - 133

繁體中文

慢性阻塞性肺病與呼吸道異常的發炎反應與氣流阻塞息息相關，急性發作時發炎反應尤其嚴重，導致呼吸道症狀的惡化，例如喘或痰液的增加。細菌及病毒感染是誘發急性發作最常見的原因，病患每年發作的次數越多，肺功能惡化、住院及死亡的風險就越大。本篇文章將會回顧慢性阻塞性肺病呼吸道發炎的機制、並討論細菌與病毒感染、氣溫、空氣汙染、嗜酸性白血球主導的發炎反應，以及其他慢性共病症如何增加呼吸道發炎與急性發作的風險。

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