淺談新一代降血糖藥物Dipeptidyl peptidase 4 inhibitor與類天疱瘡之相關性

10.6666/ClinMed.201910_84(4).0107

陳智婷；陳志強

第二型糖尿病 ； dipeptidyl peptidase-4抑制劑（DPP-4 inhibitor） ； 類天疱瘡（bullous pemphigoid）

臨床醫學月刊

84卷4期（2019 / 10 / 25）

655 - 657

繁體中文

糖尿病已成為臺灣新國病，而新型口服降血糖藥物dipeptidyl peptidase-4 inhibitor（DPP-4 inhibitor）已成為臨床使用的趨勢。過去常見副作用為腸胃相關問題，但近幾年陸續發生DPP-4 inhibitor引發類天疱瘡的個案。類天疱瘡是一種自體免疫水泡疾病，需要用到系統性類固醇及其他免疫抑制劑的治療，很容易產生感染甚至敗血症等併發症。由於全身長滿水泡，對於病人、家屬的照護上是很大的負擔。雖然目前詳細機轉並不明確，但如能越早排除DPP-4 inhibitor引發的類天疱瘡，即時停掉DPP-4 inhibitor的使用，可以降低為治療類天疱瘡而使用的類固醇劑量，減少併發症的產生。

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