胸腔病例（三六二）光動力治療

10.6666/ClinMed.202001_85(1).0010

蔡宗燁；邱昭華；趙恆勝

光動力治療（photodynamic therapy） ； 間質式光動力治療（interstitial photodynamic therapy） ； 肺癌（lung cancer） ； 非小細胞肺癌（Non-small-cell lung cancer）

臨床醫學月刊

85卷1期（2020 / 01 / 31）

58 - 62

繁體中文

光動力治療（photodynamic therapy）是用光敏劑（photosensitizer）及特定波長光線的交互作用，產生氧化自由基（free radicals），誘導細胞自然凋亡來治療非小細胞肺癌。光動力治療可有效治療早期和淺表支氣管內病變厚度小於1公分的非小細胞肺癌（non-small-cell lung cancer）。手術和化 療中合併光動力治療可改善肋膜轉移患者的生存率和預後疾病。術中光動力治療（intraoperative photodynamic therapy）可以減少非小細胞肺癌肋膜擴散。光動力治療具有高選擇性，可以破壞病變組織，對組織正常的功能和結構傷害性小，無手術、化學或放射療法的缺點，因此逐漸獲得醫學上的重視。本文章就以一位38歲女性罹患1B期肺腺癌（adenocarcinoma），接受肺葉切除術（lung lobectomy）及化療後兩年復發肺腺癌，並在接受內視鏡雷射治療後，使用光動力治療後的狀況，並引申介紹光動力治療。

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