經導管人工主動脈瓣膜植入術：現況更新與挑戰

10.6666/ClinMed.202006_85(6).0065

林廷諭；呂信邦

經導管人工主動脈瓣膜植入術（transcatheter aortic valve implantation, TAVI） ； 主動脈瓣狹窄（aortic stenosis, AS）

臨床醫學月刊

85卷6期（2020 / 06 / 26）

350 - 355

繁體中文

隨著心導管技術及醫材的進步，經導管人工主動瓣膜植入術（transcatheter aortic valve implantation, TAVI）已經成為以往令醫師們束手無策的高手術風險之主動脈瓣狹窄病患的標準治療，然而新的技術得經得起時間的考驗，減少手術併發症及改善病人預後一直是我們心臟內科醫師努力追求的目標，儘管和十幾年前相比不論是經驗、技術、術前病人的篩選、人工主動脈瓣膜的材料和設計、血管導鞘的設計等皆有大幅進步，但如果要使更多的病人能安全地接受TAVI則還有許多待解決的問題，本篇文章將針對TAVI進行系統性文獻回顧及現況更新。

1. Amat-Santos, IJ,Rodes-Cabau, J,Urena, M(2012).Incidence, predictive factors, and prognostic value of new-onset atrial fibrillation following transcatheter aortic valve implantation.J Am Coll Cardiol,59,178-188.
2. Baumgartner, H,Falk, V,Bax, JJ(2017).ESC/EACTS Guidelines for the management of valvular heart disease.Eur Heart J,38,2739-2791.
3. Bob-Manuel, T,Nanda, A,Latham, S(2018).Permanent pacemaker insertion in patients with conduction abnormalities post transcatheter aortic valve replacement: a review and proposed guidelines.Ann Transl Med,6,11.
4. Cahill, TJ,Chen, M,Hayashida, K(2018).Transcatheter aortic valve implantation: current status and future perspectives.Eur Heart J,39,2625-2634.
5. Cerrato, E,Nombela-Franco, L,Nazif, TM(2017).Evaluation of current practices in transcatheter aortic valve implantation: The WRITTEN (WoRldwIde TAVI ExperieNce) survey.Int J Cardiol,228,640-647.
6. Dvir, D,Khan, J,Kornowski, R(2018).Novel strategies in aortic valve-in-valve therapy including bioprosthetic valve fracture and BASILICA.EuroIntervention,14,Ab74-Ab82.
7. Feldman, TE,Reardon, MJ,Rajagopal, V(2018).Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacement on Mortality and Major Adverse Clinical Events in High-Risk Patients With Aortic Stenosis: The REPRISE III Randomized Clinical Trial.JAMA,319,27-37.
8. Hamm, CW,Arsalan, M,Mack, MJ(2016).The future of transcatheter aortic valve implantation.Eur Heart J,37,803-810.
9. Iung, B,Baron, G,Butchart, EG(2003).A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease.Eur Heart J,24,1231-1243.
10. Iung, B,Cachier, A,Baron, G(2005).Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery?.Eur Heart J,26,2714-2720.
11. Latib, A,Naim, C,De Bonis, M(2014).TAVRassociated prosthetic valve infective endocarditis: results of a large, multicenter registry.J Am Coll Cardiol,64,2176-2178.
12. Mack, MJ,Leon, MB,Smith, CR(2015).5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial.Lancet,385,2477-2484.
13. Miyazaki, Y,Soliman, OII,Abdelghani, M(2017).Acute performance of a novel restorative transcatheter aortic valve: preclinical results.EuroIntervention,13,e1410-e1417.
14. Mollmann, H,Hengstenberg, C,Hilker, M(2018).Real-world experience using the ACURATE neo prosthesis: 30-day outcomes of 1,000 patients enrolled in the SAVI TF registry.EuroIntervention,13,e1764-e1770.
15. Neylon, A,Ahmed, K,Mercanti, F(2018).Transcatheter aortic valve implantation: status update.J Thorac Dis,10,S3637-s3645.
16. Oguri, A,Yamamoto, M,Mouillet, G(2014).Clinical outcomes and safety of transfemoral aortic valve implantation under general versus local anesthesia: subanalysis of the French Aortic National CoreValve and Edwards 2 registry.Circ Cardiovasc Interv,7,602-610.
17. Pellikka, PA,Sarano, ME,Nishimura, RA(2005).Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up.Circulation,111,3290-3295.
18. Piccolo, R,Pilgrim, T,Franzone, A(2017).Frequency, Timing, and Impact of Access-Site and NonAccess-Site Bleeding on Mortality Among Patients Undergoing Transcatheter Aortic Valve Replacement.JACC Cardiovasc Interv,10,1436-1446.
19. Rampat, R,Khawaja, MZ,Hilling-Smith, R(2017).Conduction Abnormalities and Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement Using the Repositionable LOTUS Device: The United Kingdom Experience.JACC Cardiovasc Interv,10,1247-1253.
20. Reardon, MJ,Van Mieghem, NM,Popma, JJ(2017).Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients.N Engl J Med,376,1321-1331.
21. Ribeiro, HB,Webb, JG,Makkar, RR(2013).Predictive factors, management, and clinical outcomes of coronary obstruction following transcatheter aortic valve implantation: insights from a large multicenter registry.J Am Coll Cardiol,62,1552-1562.
22. Siontis, GC,Praz, F,Pilgrim, T(2016).Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of severe aortic stenosis: a meta-analysis of randomized trials.Eur Heart J,37,3503-3512.
23. Siu, SC,Silversides, CK(2010).Bicuspid aortic valve disease.J Am Coll Cardiol,55,2789-2800.
24. Yamamoto, M,Shimura, T,Kano, S(2016).Impact of preparatory coronary protection in patients at high anatomical risk of acute coronary obstruction during transcatheter aortic valve implantation.Int J Cardiol,217,58-63.
25. Yoon, SH,Sharma, R,Chakravarty, T(2018).Transcatheter aortic valve replacement in bicuspid aortic valve stenosis: where do we stand?.J Cardiovasc Surg,59,381-391.