放射免疫分析項目CA 72-4、NSE、17 OH-P、ASD之臨床應用

10.6666/ClinMed.202103_87(3).0027

李佳蓉；楊宛甄；黃文盛

CA 72-4 ； NSE ； 17 OH-P ； ASD ； 放射免疫分析法 ； 免疫放射分析法

臨床醫學月刊

87卷3期（2021 / 03 / 26）

168 - 173

繁體中文

放射免疫分析實驗室利用放射免疫分析法（radioimmunoassay, RIA）及免疫放射分析法（immunoradiometric assay, IRMA）體外定量檢測人體血清及血漿中待測抗原，是個靈敏度高、特異性強、精密度和準確度高的方法。本篇將介紹分析原理、分析步驟以及檢驗項目CA 72-4、NSE、17 OH-P、ASD之臨床應用與討論，提供臨床醫師疾病篩檢、診斷與治療。CA 72-4對於胃癌具有高特異性，將CA72-4、CA19-9、CEA聯合檢測，可提升檢測胃癌的靈敏度。NSE應用於肺小細胞癌及神經母細胞瘤的診斷、治療，與評估腦血管出血及腦缺氧的預後情形。分析17 OH-P濃度升高，對於21羥化酶缺乏症引起的先天性腎上腺增生症（CAH）的新生兒診斷非常重要。ASD主要評估女性多毛症、多囊性卵巢症候群、腎上腺增生、腎上腺癌、腎上腺功能、卵巢或睾丸的功能、雄性激素等激素生成狀況，多與17 OH-P搭配檢驗。

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