题名

糖尿病足感染的診斷與治療

DOI

10.6666/ClinMed.202403_93(3).0030

作者

潘意祥;陳梅君

关键词

糖尿病足感染

期刊名称

臨床醫學月刊

卷期/出版年月

93卷3期(2024 / 03 / 29)

页次

160 - 167

内容语文

繁體中文

中文摘要

糖尿病足感染是一個不斷擴大的問題,也是導致糖尿病患者住院的主要原因之一。更令人擔憂的是,糖尿病足是非創傷性截肢最常見的原因之一,而且近五成的患者在截肢後5年內死亡,其死亡率高於許多惡性腫瘤。透過適當的治療,可以降低患者截肢和死亡的風險,超過一半的糖尿病足截肢是可以透過適當治療避免的。國際糖尿病足工作組(International Working Group on the Diabetic Foot, IWGDF)自1999年開始發布糖尿病足病防治指南。該指南專注於糖尿病足感染的診斷和治療,是在2015年的糖尿病足感染指南基礎上進行的更新。這些指引強調了診斷和全面評估的重要性,未感染的糖尿病足潰瘍不應使用抗生素,也無需進行傷口培養。然而,一旦發生糖尿病足感染,就必須進行積極的診斷和治療。除了給予抗生素外,即時的外科清創、傷口護理和確保患部的血液灌流都是成功治療糖尿病足感染不可或缺的關鍵。因此,跨專業領域的團隊合作能夠有效整合各專科知識,確保病患能夠得到適切的照護。

主题分类 醫藥衛生 > 基礎醫學
醫藥衛生 > 社會醫學
参考文献
  1. Chang CH, Shau WY, Jiang YD, et al. Type 2 diabetes prevalence and incidence among adults in Taiwan during 1999-2004: a national health insurance data set study. Diabet Med 2010;27:636-43.
    連結:
  2. Whiting DR, Guariguata L, Weil C, et al. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311-21.
    連結:
  3. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA 2005;293:217-28.
    連結:
  4. Hobizal KB, Wukich DK. Diabetic foot infections: current concept review. Diabet Foot Ankle 2012.
    連結:
  5. Lavery LA, Armstrong DG, Wunderlich RP, et al. Risk factors for foot infections in individuals with diabetes. Diabetes Care 2006;29:1288-93.
    連結:
  6. 陳杰峰、陳靜敏、邱文達。品質確保與個案管理:糖尿 病足症。臺灣醫學 2008;12:209-15。
    連結:
  7. 盧道寬。臺灣地區糖尿病足部潰瘍感染之住院盛行率,醫療耗用及其影響因素之研究 - 從1996年~2004 年。高雄醫學大學醫務管理研究所碩士在職專班碩士論文。2008。
    連結:
  8. 曾立年、鄒中泰、林文翰。糖尿病患之足部感染:初報。Kaohsiung J Med Sci 1991;7:369-75。
    連結:
  9. 鄭弘裕、簡世霖。糖尿病足。慈濟醫學雜誌 2006;18:37-44。
    連結:
  10. Reiber GE, Lipsky BA, Gibbons GW. The burden of diabetic foot ulcers. Am J Surg 1998;176:5S-10S.
    連結:
  11. 周碧瑟、董道興、李佳琳,等。臺灣地區糖尿病流行病學。臺灣公共衛生雜誌 2002;21:83-96。
    連結:
  12. 陳勃仲、林承昌、陳睿俊、柯朝元。糖尿病足的評估與治療。基層醫學 2008;23:236-44。
    連結:
  13. Fincke BG, Miller DR, Turpin R. A classification of diabetic foot infections using ICD-9-CM codes: application to a large computerized medical database. BMC Health Serv Res 2010;10:192.
    連結:
  14. Armstrong DG, Wrobel J, Robbins JM. Guest Editorial: are diabetes-related wounds and amputations worse than cancer? Int Wound J 2007;4:286-7.
    連結:
  15. Lipsky BA, Berendt AR, Cornia PB, et al. 2012 infectious diseases society of america clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2012;54:e132-73.
    連結:
  16. Reiber GE, Vileikyte L, Boyko EJ, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999; 22: 157-62.
    連結:
  17. 沈惠民、林東亮、鍾進燈、許惠恒。糖尿病足之臨床評估與治療。內科學誌 2011;22:254-65。
    連結:
  18. Powlson AS, Coll AP. The treatment of diabetic foot infections. J Antimicrob Chemother 2010;65:iii3-9.
    連結:
  19. Yu HI, Sheu WH, Lai CJ, et al. Endothelial dysfunction in type 2 diabetes mellitus subjects with peripheral artery disease. Int J Cardiol 2001;78:19-25.
    連結:
  20. Yu HI, Sheu WH, Song YM, et al. C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. Diabet Med 2004;21:336-41.
    連結:
  21. Bagdade JD, Root RK, Bulger RJ. Impaired leukocyte function in patients with poorly controlled diabetes. Diabetes 1974;23:9-15.
    連結:
  22. Delamaire M, Maugendre D, Moreno M, et al. Impaired leucocyte functions in diabetic patients. Diabet Med 1997;14:29-34.
    連結:
  23. Lipsky BA, Berendt AR, Deery HG, et al. Diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2004;39:885-910.
    連結:
  24. Schaper NC, Apelqvist J, Bakker K. The international consensus and practical guidelines on the management and prevention of the diabetic foot. Curr Diab Rep 2003;3:475-9.
    連結:
  25. Vedhara K, Miles JN, Wetherell MA, et al. Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence. Diabetologia 2010; 53: 1590-8.
    連結:
  26. Armstrong DG, Lavery LA, Sariaya M, Ashry H. Leukocytosis is a poor indicator of acute osteomyelitis of the foot in diabetes mellitus. J Foot Ankle Surg 1996;35:280-3.
    連結:
  27. Prompers L, Schaper N, Apelqvist J, et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia 2008;51:747-55.
    連結:
  28. Lavery LA, Armstrong DG, Murdoch DP, et al. Validation of the Infectious Diseases Society of America's diabetic foot infection classification system. Clin Infect Dis 2007;44:562-5.
    連結:
  29. Lipsky BA, Sheehan P, Armstrong DG, et al. Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial. Int Wound J 2007;4:30-8.
    連結:
  30. Butalia S, Palda VA, Sargeant RJ, et al. Does this patient with diabetes have osteomyelitis of the lower extremity? JAMA 2008;299:806-13.
    連結:
  31. Akinci B, Yener S, Yesil S, et al. Acute phase reactants predict the risk of amputation in diabetic foot infection. J Am Podiatr Med Assoc 2011;101:1-6.
    連結:
  32. Lin CW, Hsu LA, Chen CC, et al. C-reactive protein as an outcome predictor for percutaneous transluminal angioplasty in diabetic patients with peripheral arterial disease and infected foot ulcers. Diabetes Res Clin Pract 2010;90:167-72.
    連結:
  33. Lipsky BA, Armstrong DG, Citron DM, et al. Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, doubleblinded, multicentre trial. Lancet 2005;366:1695-703.
    連結:
  34. Termaat MF, Raijmakers PG, Scholten HJ, et al. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am 2005;87:2464-71.
    連結:
  35. Senneville E, Morant H, Descamps D, et al. Needle puncture and transcutaneous bone biopsy cultures are inconsistent in patients with diabetes and suspected osteomyelitis of the foot. Clin Infect Dis 2009;48:888-93.
    連結:
  36. Tascini C, Piaggesi A, Tagliaferri E, et al. Microbiology at first visit of moderate-to-severe diabetic foot infection with antimicrobial activity and a survey of quinolone monotherapy. Diabetes Res Clin Pract 2011;94:133-9.
    連結:
  37. Dang CN, Prasad YD, Boulton AJ, et al. Methicillinresistant Staphylococcus aureus in the diabetic foot clinic: a worsening problem. Diabet Med 2003;20:159-61.
    連結:
  38. Vardakas KZ, Horianopoulou M, Falagas ME. Factors associated with treatment failure in patients with diabetic foot infections: An analysis of data from randomized controlled trials. Diabetes Res Clin Pract 2008;80:344-51.
    連結:
  39. Kandemir O, Akbay E, Sahin E, et al. Risk factors for infection of the diabetic foot with multi-antibiotic resistant microorganisms. J Infect 2007;54:439-45.
    連結:
  40. Lipsky BA. Diabetic foot infections: microbiology made modern? Array of hope. Diabetes Care 2007;30:2171-2.
    連結:
  41. Chakraborti C, Le C, Yanofsky A. Sensitivity of superficial cultures in lower extremity wounds. J Hosp Med 2010;5:415-20.
    連結:
  42. Chantelau E, Tanudjaja T, Altenhofer F, et al. Antibiotic treatment for uncomplicated neuropathic forefoot ulcers in diabetes: a controlled trial. Diabet Med 1996;13:156-9.
    連結:
  43. Crouzet J, Lavigne JP, Richard JL, Sotto A. Diabetic foot infection: a critical review of recent randomized clinical trials on antibiotic therapy. Int J Infect Dis 2011;15:e601-10.
    連結:
  44. 丁毅。非創傷性糖尿病足趾截肢健保費用分析。臺北醫學大學傷害防治學研究所碩士論文。2006。
  45. Sheen YJ, Lin JL, Lee IT, et al. Low estimated glomerular filtration rate is a major determinant of low ankle-brachial index and toe-brachial index in type 2 diabetes. Angiology 2011;63:55-61.
  46. Schwegler B, Stumpe KD, Weishaupt D, et al. Unsuspected osteomyelitis is frequent in persistent diabetic foot ulcer and better diagnosed by MRI than by 18F-FDG PET or 99mTcMOAB. J Intern Med 2008;263:99-106.
  47. Strbova L, Krahulec B, Waczulikova I, et al. Influence of infection on clinical picture of diabetic foot syndrome. Bratisl Lek Listy 2011;112:177-82.
  48. Diamantopoulos EJ, Haritos D, Yfandi G, et al. Management and outcome of severe diabetic foot infections. Exp Clin Endocrinol Diabetes 1998;106:346-52.