糞便微生物移植對於腸躁症患者之療效

10.6666/ClinMed.202403_93(3).0031

賴信樺；李癸汌

腸胃道微生物菌叢（guts microbiota） ； 糞便微生物移植（fecal microbiota transplantation） ； 腸躁症（irritable bowel syndrome） ； 腸胃道功能性障礙（functional gastrointestinal disorders）

臨床醫學月刊

93卷3期（2024 / 03 / 29）

168 - 172

繁體中文

腸躁症為常見的腸胃道功能性障礙且目前真正致病機轉仍存在許多理論假說，而近幾年有許多研究嘗試將糞便微生物移植運用在更廣泛的腸道疾病，其中也包含了腸躁症。這篇文章分析了近10年內針對糞便微生物移植對於腸躁症患者的隨機對照試驗成果做比較。在最後納入分析的5篇文章中，其中4篇文章皆使用內視鏡進行異體糞便移植而在最後統計結果中，症狀相較於治療前上都有顯著的改善。4篇研究中的兩篇文章更發現，異體糞便移植相較於自體糞便移植具有顯著的組間差異。唯一一篇文章採用口服糞便移植膠囊，其結果則是與其他4篇文章相反。5篇糞便移植的不良反應都是相對輕微的。因此，異體糞便微生物移植對於腸躁症患者之成果是有效且看好的。然而，後續針對亞洲族群以及比較其他腸躁症治療的研究及分析也是必要的。

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